David A Joy - Denali Therapeut Inc | 人才画像

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论文共 41 篇作者统计合作学者相似作者

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Novel High-Content and Open-Source Image Analysis Tools for Profiling Mitochondrial Morphology in Neurological Cell Models

Marcus Y. Chin,David A. Joy, Madhuja Samaddar,Anil Rana,Johann Chow,Takashi Miyamoto,Meredith Calvert

SLAS DISCOVERY (2025)

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Fc-engineered Large Molecules Targeting Blood-Brain Barrier Transferrin Receptor and CD98hc Have Distinct Central Nervous System and Peripheral Biodistribution

Nathalie Khoury,Michelle E Pizzo, Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha, Gabrielly L De Melo, Lily Sarrafha, Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow, Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker, Holly Kane,Amy Leung, Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk, Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Nature communicationsno. 1 (2025): 1822-1822

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Fc-engineered Large Molecules Targeting Blood-Brain Barrier Transferrin Receptor and CD98hc Have Distinct Central Nervous System and Peripheral Biodistribution Compared to Standard Antibodies

Nathalie Khoury,Michelle E Pizzo, Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha, Gabrielly L De Melo, Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie Chew,Johann Chow, Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker, Holly Kane,Amy Leung, Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk, Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

biorxiv（2024）

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Engineering Anti-Amyloid Antibodies with Transferrin Receptor Targeting Improves Safety and Brain Biodistribution

Michelle E Pizzo,Edward D Plowey,Nathalie Khoury,Wanda Kwan, Jordan Abettan,Sarah L DeVos, Claire B Discenza,Timothy Earr,David Joy, Ming Lye-Barthel,Elysia Roche,Darren Chan,Jason C Dugas,Kapil Gadkar,René Meisner,Jennifer Sebalusky, Ana Claudia Silva Amaral,Isabel Becerra,Roni Chau,Johann Chow, Allisa J Clemens,Mark S Dennis,Joseph Duque, Laura Fusaro,Jennifer A Getz,Mihalis S Kariolis,Do Jin Kim,Amy Wing-Sze Leung,Hoang N Nguyen,Elliot R Thomsen,Pascal E Sanchez, Lu Shan,Adam P Silverman,Hilda Solanoy,Raymond Tong,Meredith E K Calvert,Ryan J Watts,Robert G Thorne,Paul H Weinreb, Dominic M Walsh,Joseph W Lewcock,Thierry Bussiere,Y. Joy Yu Zuchero

biorxiv（2024）

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ETV:SGSH, a Brain-Penetrant Enzyme Transport Vehicle for SGSH, Improves Lysosomal and Microglial Morphology, Degeneration and Cognitive Behavior in MPS IIIA Mice

Shababa T. Masoud,Hoang Nguyen,Claire Discenza,David Joy,Jeffrey Simms,Iris Lo, You Young Chun,Julia Holtzman, Khishig Tsogtbaatar,Amy Wing-Sze Leung,Isabel Becerra,Elliot Thomsen,Audrey Gill,Yashas Rajendra,Alexander Seay,Mohammad Jafarnejad,Anna Bakardjiev,Meredith E. K. Calvert,Cathal S. Mahon, Robert Thorne, Steven Chessler,Kirk Henne,Pascal Sanchez,Annie Arguello

Molecular Genetics and Metabolismno. 2 (2024): 107954

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Transferrin Receptor-Mediated Transport at the Blood-Brain Barrier is Elevated in Early Development but Maintained Across Adult Aging

Vanessa O. Torres,Michelle E Pizzo,Darren Chan,Jason C Dugas,David Huynh,David Joy, Eric K. Liang, Lily Sarrafha,Isabel Becerra,Roni Chau,Kylie S. Chew,Johann Chow,Timothy K. Earr,Nathalie Khoury,Kendra J. Lechtenberg, Amy W. Leung,Hoang N. Nguyen, Emmanuel S. Ojo,Elysia Roche,Hilda Solanoy,Mabel Tong,Raymond K. Tong,Kirk Henne,Joseph W. Lewcock,Ryan J. Watts, Meredith E. Calvert, Robert G. Thorne,Joy Zuchero

biorxiv（2024）

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Rab12 regulates LRRK2 activity by promoting its localization to lysosomes

Vitaliy V. Bondar,Xiang Wang,Oliver B. Davis,Michael T. Maloney,Maayan Agam,Marcus Y. Chin,Audrey Cheuk-Nga Ho,David Joy,Joseph W. Lewcock,Gilbert Di Paolo, Robert G. Thorne,Zachary K. Sweeney,Anastasia G. Henry

biorxiv（2023）

引用4浏览0引用

Rab12 is a Regulator of LRRK2 and Its Activation by Damaged Lysosomes

Xiang Wang,Vitaliy V. Bondar,Oliver B. Davis,Michael T. Maloney,Maayan Agam,Marcus Y. Chin,Audrey Cheuk-Nga Ho,Rajarshi Ghosh,Dara E. Leto,David Joy,Meredith E. K. Calvert,Joseph W. Lewcock,Gilbert Di Paolo, Robert G. Thorne,Zachary K. Sweeney,Anastasia G. Henry

ELIFE (2023)

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Author Response: Rab12 is a Regulator of LRRK2 and Its Activation by Damaged Lysosomes

Xiang Wang,Vitaliy V Bondar,Oliver B Davis,Michael T Maloney,Maayan Agam,Marcus Y Chin,Audrey Cheuk-Nga Ho,Rajarshi Ghosh,Dara E Leto,David Joy,Meredith EK Calvert,Joseph W Lewcock,Gilbert Di Paolo, Robert G Thorne,Zachary K Sweeney,Anastasia G Henry

openalex（2023）

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CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023)

NATURE COMMUNICATIONSno. 1 (2023)

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