Amy Wing-Sze Leung - Department of Computer Science, The University of Hong Kong

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Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

Nathalie Khoury,Michelle E Pizzo, Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha, Gabrielly L De Melo, Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie Chew,Johann Chow, Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker, Holly Kane,Amy Leung, Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

biorxiv（2024）

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Engineering anti-amyloid antibodies with transferrin receptor targeting improves safety and brain biodistribution

Michelle E Pizzo,Edward D Plowey,Nathalie Khoury,Wanda Kwan, Jordan Abettan,Sarah L DeVos, Claire B Discenza,Timothy Earr,David Joy, Ming Lye-Barthel,Elysia Roche,Darren Chan,Jason C Dugas,Kapil Gadkar,René Meisner,Jennifer Sebalusky, Ana Claudia Silva Amaral,Isabel Becerra,Roni Chau,Johann Chow, Allisa J Clemens,Mark S Dennis,Joseph Duque, Laura Fusaro,Jennifer A Getz,Mihalis S Kariolis,Do Jin Kim,Amy Wing-Sze Leung,Hoang N Nguyen,Elliot R Thomsen,Pascal E Sanchez, Lu Shan,Adam P Silverman,Hilda Solanoy,Raymond Tong,Meredith E K Calvert,Ryan J Watts,Robert G Thorne, Paul H Weinreb, Dominic M Walsh,Joseph W Lewcock,Thierry Bussiere,Y. Joy Yu Zuchero

biorxiv（2024）

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ETV:SGSH, a Brain-Penetrant Enzyme Transport Vehicle for SGSH, Improves Lysosomal and Microglial Morphology, Degeneration and Cognitive Behavior in MPS IIIA Mice

Shababa T. Masoud,Hoang Nguyen,Claire Discenza,David Joy,Jeffrey Simms,Iris Lo, You Young Chun,Julia Holtzman, Khishig Tsogtbaatar,Amy Wing-Sze Leung,Isabel Becerra,Elliot Thomsen,Audrey Gill,Yashas Rajendra,Alexander Seay,Mohammad Jafarnejad,Anna Bakardjiev,Meredith E. K. Calvert,Cathal S. Mahon,Robert Thorne, Steven Chessler,Kirk Henne,Pascal Sanchez,Annie Arguello

MOLECULAR GENETICS AND METABOLISMno. 2 (2024)

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Reviewer #3 (public Review): DNL343 is an Investigational CNS Penetrant Eif2b Activator That Prevents and Reverses the Effects of Neurodegeneration Caused by the Integrated Stress Response

Ernie Yulyaningsih, J. H. Suh, Melania H. Fanok,Roni Chau,Hilda Solanoy,Ryan H. Takahashi,Anna I. Bakardjiev,Isabel Becerra, N. Butch Benitez,Chi‐Lu Chiu,Sonnet S. Davis,William E. Dowdle,Timothy Earr,Anthony A. Estrada,Audrey Gill,Connie Ha,Patrick C. G. Haddick,Kirk R. Henne,Martin Larhammar,Amy Wing-Sze Leung,Romeo Maciuca, Bahram Memarzadeh,Hoang N. Nguyen,Alicia Nugent,Maksim Osipov, Yingqing Ran, Kevin Rebadulla,Elysia Roche,Thomas Sandmann,Jing Wang,Joseph W. Lewcock,Kimberly Scearce‐Levie,Lesley A. Kane,Pascal E. Sanchez

openalex（2024）

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Long-Read Sequencing with Hierarchical Clustering for Antiretroviral Resistance Profiling of Mixed Human Immunodeficiency Virus Quasispecies

Timothy Ting-Leung Ng,Junhao Su,Hiu-Yin Lao, Wui-Wang Lui,Chloe Toi-Mei Chan,Amy Wing-Sze Leung,Stephanie Hoi-Ching Jim,Lam-Kwong Lee,Sheeba Shehzad,Kingsley King-Gee Tam,Kenneth Siu-Sing Leung, Forrest Tang,Wing-Cheong Yam,Ruibang Luo,Gilman Kit-Hang Siu

Clinical chemistry（2023）

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CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023)

NATURE COMMUNICATIONSno. 1 (2023)

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A TREM2-activating Antibody with a Blood–brain Barrier Transport Vehicle Enhances Microglial Metabolism in Alzheimer’s Disease Models

Bettina van Lengerich,Lihong Zhan,Dan Xia,Darren Chan,David Joy,Joshua I. Park,David Tatarakis,Meredith Calvert,Selina Hummel,Steve Lianoglou,Michelle E. Pizzo,Rachel Prorok,Elliot Thomsen,Laura M. Bartos,Philipp Beumers,Anja Capell,Sonnet S. Davis, Lis de Weerd,Jason C. Dugas,Joseph Duque,Timothy Earr,Kapil Gadkar,Tina Giese,Audrey Gill,Johannes Gnörich,Connie Ha,Malavika Kannuswamy,Do Jin Kim,Sebastian T. Kunte,Lea H. Kunze,Diana Lac,Kendra Lechtenberg,Amy Wing-Sze Leung,Chun-Chi Liang,Isabel Lopez,Paul McQuade, Anuja Modi,Vanessa O. Torres,Hoang N. Nguyen, Ida Pesämaa,Nicholas Propson,Marvin Reich,Yaneth Robles-Colmenares,Kai Schlepckow,Luna Slemann,Hilda Solanoy,Jung H. Suh,Robert G. Thorne, Chandler Vieira,Karin Wind-Mark, Ken Xiong,Y. Joy Yu Zuchero,Dolo Diaz,Mark S. Dennis,Fen Huang,Kimberly Scearce-Levie,Ryan J. Watts,Christian Haass,Joseph W. Lewcock,Gilbert Di Paolo,Matthias Brendel,Pascal E. Sanchez,Kathryn M. Monroe

Nature neuroscience (2023)

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CD98hc is a Target for Brain Delivery of Biotherapeutics

Nature communications（2023）

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Evaluation of Mycobacterium Tuberculosis Enrichment in Metagenomic Samples Using ONT Adaptive Sequencing and Amplicon Sequencing for Identification and Variant Calling

Junhao Su,Wui Wang Lui,YanLam Lee,Zhenxian Zheng,Gilman Kit-Hang Siu,Timothy Ting-Leung Ng,Tong Zhang,Tommy Tsan-Yuk Lam,Hiu-Yin Lao,Wing-Cheong Yam,Kingsley King-Gee Tam,Kenneth Siu-Sing Leung,Tak-Wah Lam,Amy Wing-Sze Leung,Ruibang Luo

Scientific Reports（2023）

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