Kapil Gadkar - Preclinical and Translational Pharmacokinetics Department, Genentech, Inc

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Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Scarlett J. Barker,Mai B. Thayer,Chaeyoung Kim,David Tatarakis,Matthew J. Simon, Rebekah Dial, Lizanne Nilewski,Robert C. Wells,Yinhan Zhou,Megan Afetian,Padma Akkapeddi,Alfred Chappell,Kylie S. Chew,Johann Chow, Allisa Clemens, Claire B. Discenza,Jason C. Dugas,Chrissa Dwyer,Timothy Earr,Connie Ha, Yvonne S. Ho,David Huynh, Edwin I. Lozano, Srini Jayaraman,Wanda Kwan,Cathal Mahon,Michelle Pizzo,Yaneth Robles-Colmenares,Elysia Roche, Laura Sanders, Alexander Stergioulis,Raymond Tong,Hai Tran,Joy Yu Zuchero,Anthony A. Estrada,Kapil Gadkar, Christopher M. M. Koth,Pascal E. Sanchez,Robert G. Thorne, Ryan J. Watts,Thomas Sandmann,Lesley A. Kane,Frank Rigo, Mark S. Dennis,Joseph W. Lewcock,Sarah L. Devos

SCIENCE TRANSLATIONAL MEDICINEno. 760 (2024)

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Engineering anti-amyloid antibodies with transferrin receptor targeting improves safety and brain biodistribution

Michelle E Pizzo,Edward D Plowey,Nathalie Khoury,Wanda Kwan, Jordan Abettan,Sarah L DeVos, Claire B Discenza,Timothy Earr,David Joy, Ming Lye-Barthel,Elysia Roche,Darren Chan,Jason C Dugas,Kapil Gadkar,René Meisner,Jennifer Sebalusky, Ana Claudia Silva Amaral,Isabel Becerra,Roni Chau,Johann Chow, Allisa J Clemens, Mark S Dennis,Joseph Duque, Laura Fusaro,Jennifer A Getz,Mihalis S Kariolis,Do Jin Kim,Amy Wing-Sze Leung,Hoang N Nguyen,Elliot R Thomsen,Pascal E Sanchez, Lu Shan,Adam P Silverman,Hilda Solanoy,Raymond Tong,Meredith E K Calvert, Ryan J Watts,Robert G Thorne, Paul H Weinreb, Dominic M Walsh,Joseph W Lewcock,Thierry Bussiere,Y. Joy Yu Zuchero

biorxiv（2024）

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Industry Perspective on First-in-Human and Clinical Pharmacology Strategies to Support Clinical Development of T-Cell Engaging Bispecific Antibodies for Cancer Therapy

Prathap Nagaraja Shastri, Nirav Shah, Martin Lechmann,Hardik Mody,Marc W Retter,Min Zhu,Tommy Li,Jun Wang, Naveed Shaik,Xirong Zheng,Meric Ovacik,Fei Hua,Vibha Jawa,Christophe Boetsch,Yanguang Cao, John Burke,Kaushik Datta,Kapil Gadkar,Vijay Upreti,Alison Betts

Clinical pharmacology and therapeutics (2024)

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Iraj Hosseini,Brett Fleisher,Jennifer Getz,Jeremie Decalf,Mandy Kwong,Meric Ovacik,Travis W. Bainbridge,Christine Moussion,Gautham K. Rao,Kapil Gadkar,Amrita V. Kamath,Saroja Ramanujan

PHARMACEUTICSno. 5 (2024)

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Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J Barker,Mai B Thayer,Chaeyoung Kim,David Tatarakis,Matthew Simon, Rebekah L Dial, Lizanne Nilewski,Robert C Wells,Yinhan Zhou,Megan Afetian,Alfred Chappell,Kylie S Chew,Johann Chow, Allisa Clemens, Claire B Discenza,Jason Dugas,Chrissa Dwyer,Timothy Earr,Connie Ha,David Huynh, Srini Jayaraman,Wanda Kwan,Cathal Mahon,Michelle Pizzo,Elysia Roche, Laura Sanders, Alexander Stergioulis,Raymond Tong,Hai Tran,Joy Zuchero,Anthony A Estrada,Kapil Gadkar, Christopher MM Koth,Pascal E Sanchez,Robert G Thorne,Ryan J Watts,Thomas Sandmann,Lesley Kane,Frank Rigo, Mark S Dennis,Joseph W Lewcock,Sarah L DeVos

bioRxiv (Cold Spring Harbor Laboratory) (2023)

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CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023)

NATURE COMMUNICATIONSno. 1 (2023)

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A TREM2-activating Antibody with a Blood–brain Barrier Transport Vehicle Enhances Microglial Metabolism in Alzheimer’s Disease Models

Bettina van Lengerich,Lihong Zhan,Dan Xia,Darren Chan,David Joy,Joshua I. Park,David Tatarakis,Meredith Calvert,Selina Hummel,Steve Lianoglou,Michelle E. Pizzo,Rachel Prorok,Elliot Thomsen,Laura M. Bartos,Philipp Beumers,Anja Capell,Sonnet S. Davis, Lis de Weerd,Jason C. Dugas,Joseph Duque,Timothy Earr,Kapil Gadkar,Tina Giese,Audrey Gill,Johannes Gnörich,Connie Ha,Malavika Kannuswamy,Do Jin Kim,Sebastian T. Kunte,Lea H. Kunze,Diana Lac,Kendra Lechtenberg,Amy Wing-Sze Leung,Chun-Chi Liang,Isabel Lopez,Paul McQuade, Anuja Modi, Vanessa O. Torres,Hoang N. Nguyen, Ida Pesämaa,Nicholas Propson,Marvin Reich,Yaneth Robles-Colmenares,Kai Schlepckow,Luna Slemann,Hilda Solanoy,Jung H. Suh,Robert G. Thorne, Chandler Vieira,Karin Wind-Mark, Ken Xiong,Y. Joy Yu Zuchero,Dolo Diaz,Mark S. Dennis,Fen Huang,Kimberly Scearce-Levie, Ryan J. Watts,Christian Haass,Joseph W. Lewcock,Gilbert Di Paolo,Matthias Brendel,Pascal E. Sanchez,Kathryn M. Monroe

Nature neuroscience (2023)

引用21浏览0WOSNATURE引用

CD98hc is a Target for Brain Delivery of Biotherapeutics

Nature communications（2023）

引用2浏览0WOSNATURE引用

Systems-based Digital Twins to Help Characterize Clinical Dose-Response and Propose Predictive Biomarkers in a Phase I Study of Bispecific Antibody, Mosunetuzumab, in NHL

Monica E. Susilo,Chi-Chung Li,Kapil Gadkar,Genevive Hernandez,Ling-Yuh Huw,Jin Y. Jin,Shen Yin,Michael C. Wei,Saroja Ramanujan,Iraj Hosseini

Clinical and translational science（2023）

引用4浏览0WOS引用

Biotherapeutics ADME and PK/PD Principles

Daniela Bumbaca Yadav,Kapil Gadkar,Isabel Figueroa

Haschek and Rousseaux's Handbook of Toxicologic Pathologypp.77-100, (2022)

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