Research Interests RNA genomics and bioinformatics: Functions and regulations of non-coding RNAs in biological processes and diseases; Genotype-phenotype relationships in complex diseases or traits; Software development for high-throughput data analysis; Applications in synthetic biology Representative Publications JW Li, HM Lee, Y Wang, AH Tong, KY Yip, SK Tsui, S Lok, R Ozaki, AO Luk, AP Kong, WY So, RC Ma, JC Chan, and TF Chan. (2016) Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes. Sci Rep 6:35228. AK Leung, TP Kwok, R Wan, M Xiao, PY Kwok, KY Yip, and TF Chan. (2016) OMBlast: Alignment Tool for Optical Mapping Using a Seed-and-extend Approach. Bioinformatics (in press) SY Wang, K Lau, KP Lai, JW Zhang, AC Tse, JW Li, Y Tong, TF Chan, CK Wong, JM Chiu, DW Au, AS Wong, RY Kong, RS Wu. (2016) Hypoxia causes transgenerational impairments in reproduction of fish. Nat Commun 7:12114. TF Chan, KM Ji, KY Yim, XY Liu, JW Zhou, RQ Li, KY Yang, J Li, M Li, PT Law, YL Wu, ZL Cai, H Qin, Y Bao, RK Leung, PK Ng, J Zou, XJ Zhong, PX Ran, NS Zhong, ZG Liu, and SK Tsui. (2015) The draft genome, transcriptome and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens. J Allergy Clin Immunol 135(2):539-48. H Tsoi, CS Yu, ZS Chen, NK Ng, AY Chan, LY Yuen, JM Abrigo, SY Tsang, SK Tsui, TM Tong, IF Lo, ST Lam, VC Mok, LK Wong, JC Ngo, KF Lau, TF Chan*, HY Chan* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J Med Genet 51(9):590-5. (*co-corresponding) SK Lou, HM Lee, H Qin, JW Li, Z Gao, X Liu, LL Chan, VK Lam, WY So, Y Wang, S Lok, J Wang, RC Ma, SK Tsui, JC Chan*, TF Chan*, and KY Yip* (2014) Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation. Genome Biol 15(7):408. (*co-corresponding) X Qi, MW Li, M Xie, X Liu, M Ni, G Shao, C Song, AK Yim, Y Tao, FL Wong, S Isobe, CF Wong, KS Wong, C Xu, C Li, Y Wang, R Guan, F Sun, G Fan, Z Xiao, F Zhou, TH Phang, X Liu, SW Tong, TF Chan, SM Yiu, S Tabata, J Wang, X Xu, and HM Lam. (2014) Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing. Nat Commun 9;5:4340. CC Lau, TT Sun, AK Ching, M He, JW Li, AM Wong, NN Co, AW Chan, PS Li, RW Lung, JH Tong, PB Lai, HL Chan, KF To, TF Chan*, N Wong*. (2014) Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell 25(3):335-349. (*Co-corresponding) PT Law, H Qin, AK Ching, KP Lai, NN Co, M He, RW Lung, AW Chan, TF Chan*, and N Wong*. (2013) Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma. J Hepatol 58(6):1165-73. (*co-corresponding) JW Li, R Wan, CS Yu, NN Co, N Wong, and TF Chan*. (2013) ViralFusionSeq: Accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution. Bioinformatics 29(5):649-51.