Nikolai Makukhin - Charles Univ Prague, Dept Organ Chem, Fac Sci, Hlavova 2030-8, Prague 12843 2, Czech Republic

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论文共 17 篇作者统计合作学者相似作者

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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation Via a Heterotrivalent Proteolysis Targeting Chimera

Adam G Bond, Miquel Muñoz I Ordoño, Celia M Bisbach,Conner Craigon,Nikolai Makukhin,Elizabeth A Caine, Manjula Nagala,Marjeta Urh,Georg E Winter, Kristin M Riching,Alessio Ciulli

Journal of the American Chemical Societyno. 49 (2024): 33675-33711

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Mechanism of Degrader-Targeted Protein Ubiquitinability

Charlotte Crowe,Mark A Nakasone, Sarah Chandler,Conner Craigon, Gajanan Sathe,Michael H Tatham,Nikolai Makukhin,Ronald T Hay,Alessio Ciulli

Science advancesno. 41 (2024): eado6492-eado6492

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Structure-based Design of a Phosphotyrosine-Masked Covalent Ligand Targeting the E3 Ligase SOCS2

Sarath Ramachandran,Nikolai Makukhin,Kevin Haubrich,Manjula Nagala, Beth Forrester, Dylan M. Lynch,Ryan Casement,Andrea Testa,Elvira Bruno,Rosaria Gitto,Alessio Ciulli

Nature Communicationsno. 1 (2023)

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Discovery of benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

Alessandra Cipriano,Ciro Milite,Alessandra Feoli,Monica Viviano,Giacomo Pepe,Pietro Campiglia,Giuliana Sarno,Sarah Picaud,Satomi Imaide,Nikolai Makukhin,Panagis Filippakopoulos,Alessio Ciulli,Sabrina Castellano,Gianluca Sbardella

ChemMedChemno. 20 (2022)

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Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2

Xingui Liu,Alexia F. Kalogeropulou,Sofia Domingos,Nikolai Makukhin,Raja S. Nirujogi,Francois Singh,Natalia Shpiro, Anton Saalfrank,Esther Sammler,Ian G. Ganley,Rui Moreira,Dario R. Alessi,Alessio Ciulli

Journal of the American Chemical Societyno. 37 (2022): 16930-16952

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Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides As Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (chemmedchem 20/2022)

ChemMedChem（2022）

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Recent Advances in Synthetic and Medicinal Chemistry of Phosphotyrosine and Phosphonate-Based Phosphotyrosine Analogues

Nikolai Makukhin,Alessio Ciulli

RSC medicinal chemistryno. 1 (2021): 8-23

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Targeting Non-Canonical Activation of GLI1 by the SOX2-BRD4 Transcriptional Complex Improves the Efficacy of HEDGEHOG Pathway Inhibition in Melanoma

Silvia Pietrobono,Eugenio Gaudio,Sinforosa Gagliardi, Mariapaola Zitani,Laura Carrassa,Francesca Migliorini,Elena Petricci,Fabrizio Manetti,Nikolai Makukhin,Adam G. Bond,Brooke D. Paradise,Alessio Ciulli,Martin E. Fernandez-Zapico,Francesco Bertoni,Barbara Stecca

Oncogene（2021）

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Structural Insights into Substrate Recognition by the SOCS2 E3 Ubiquitin Ligase

Wei-Wei Kung,Sarath Ramachandran,Nikolai Makukhin,Elvira Bruno,Alessio Ciulli

Nature Communications（2019）

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