Structure-based Design of a Phosphotyrosine-Masked Covalent Ligand Targeting the E3 Ligase SOCS2

Sarath Ramachandran,Nikolai Makukhin,Kevin Haubrich,Manjula Nagala, Beth Forrester, Dylan M. Lynch,Ryan Casement,Andrea Testa,Elvira Bruno,Rosaria Gitto,Alessio Ciulli

Nature Communications（2023）

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Chemical modification,Chemical tools,Small molecules,Structure-based drug design,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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