His research activity concerns integrated physiology and functional genomics in microbial systems, with a specific focus on genetic and metabolic regulation and refactoring of carbon and energy metabolism. He is author ofr200 papers in International journal and holds 20 patents. He is Editor in Chief of BMC Biotechnology for Biofuels and Specialty Editor in Chief of Frontiers in Bioengineering and Biotechnology, section Synthetic Biology as well as member of the European Federation of Biotechnology Research Interests: 1. Microbial metabolism and physiology 2. Cell wall assembly and structure 3. Microbial Metabolic engineering 4. Synthetic biology