His career has focused on the use of human genetics for identification of novel pathways involved in metabolic and cardiovascular phenotypes and diseases, and studies in both model systems and humans with the goal of elucidating molecular and physiological mechanisms. He has also pursued the implications of his work for translational therapeutics and precision medicine. He has long been engaged in human genetics discovery of both Mendelian lipid disorders and complex traits. In that context he has led projects involving genotype-directed deep phenotyping of individuals with Mendelian conditions or rare mutations, as well as recruitment of large numbers of participants with these phenotypes. He directs a functional genomics laboratory where he and his research team attempt to discern the biology of pathways identified through human genetics studies. He has a strong interest and track record of using translational approaches to use the biological information generated in the lab, for development of novel therapeutic approaches.