Chemical biology of cell signaling and regulation: Optical Imaging of cellular processes and development of molecular sensors: Small molecule modulation of cell signaling: New regulatory roles of membrane lipids and lipid binding proteins Cellular processes, such as cell signaling, are mediated by myriad of protein-protein interactions that are exquisitely coordinated and tightly regulated. Our recent studies have shown that membrane lipids play key roles in this complex regulation. Our current research focuses on i) understanding how lipids perform their regulatory actions, ii) discovering their new cellular functions, iii) and developing new therapeutics and novel strategies to treat diverse human diseases caused by dysfunctional lipid-regulated processes, including cancer, autoimmune diseases, inflammatory diseases, and metabolic diseases.