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个人简介
In the Haucke laboratory we aim to understand cellular communication in health and disease at the level of membrane-enclosed compartments that dynamically exchange materials between them. Our main focus is on the analysis of the endocytic and endolysosomal systems in genome-engineered cells and in nerve tissue. The laboratory uses a broad range of techniques including biochemical and molecular biology approaches, super-resolution light and electron microscopy, chemical biology and screening technology, electrophysiology as well as genetic and genome engineering in cell-based models and in vivo.
The overarching goal of our research is to understand the basic principles that enable proteins and lipids to control membrane flux within cells and, thereby, regulate cell and tissue function with a focus on the nervous system. We use this know-how to develop novel strategies for pharmacological or genetic interference that can pave the way to cure diseases including epilepsy, neurodegeneration, lysosomal disorders, myopathies, and cancer.
The overarching goal of our research is to understand the basic principles that enable proteins and lipids to control membrane flux within cells and, thereby, regulate cell and tissue function with a focus on the nervous system. We use this know-how to develop novel strategies for pharmacological or genetic interference that can pave the way to cure diseases including epilepsy, neurodegeneration, lysosomal disorders, myopathies, and cancer.
研究兴趣
论文共 369 篇作者统计合作学者相似作者
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Kristine Oevel, Svea Hohensee,Atul Kumar, Irving Rosas-Brugada,Francesca Bartolini, Tolga Soykan,Volker Haucke
crossref(2024)
Vera Magg, Alessandro Manetto,Katja Kopp, Chia Ching Wu, Mohsen Naghizadeh,Doris Lindner,Lucy Eke, Julia Welsch,Stefan M. Kallenberger,Johanna Schott,Volker Haucke,Nicolas Locker,
STAR Protocolsno. 2 (2024): 102945-102945
Fabian Lukas,Claudia Matthaeus,Tania López-Hernández, Ines Lahmann, Nicole Schultz,Martin Lehmann,Dmytro Puchkov, Jan Pielage,Volker Haucke,Tanja Maritzen
Nature Communicationsno. 1 (2024): 1-15
BIOspektrumno. 2 (2024): 135-135
Kristine Oevel, Svea Hohensee,Atul Kumar, Irving Rosas-Brugada,Francesca Bartolini,Tolga Soykan,Volker Haucke
ELIFE (2024)
Trends in Cell Biology (2024)
The Journal of biological chemistryno. 3 (2024): 105757-105757
Michael Ebner,Dmytro Puchkov, Orestes López-Ortega, Pathma Muthukottiappan, Yanwei Su,Christopher Schmied, Silke Zillmann, Iryna Nikonenko, Jochen Koddebusch,Gillian L Dornan, Max T Lucht,Vonda Koka,
Cellno. 24 (2023): 5328-5346.e26
Vera Magg, Alessandro Manetto,Katja Kopp, Julia Welsch,Lucy Eke, Stephan M Kallenberger,Volker Haucke,Nicolas Locker,Georg Stoecklin,Alessia Ruggieri
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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