My research interests include the control of cellular energy utilization with emphasis on mitochondrial function as affected by diabetes and obesity. I am also investigating the mechanisms by which mitochondria regulate reactive oxygen production and the relationship of oxygen radicals to the pathophysiology of diabetes and obesity. My laboratory has extensive experience and has generated several publications regarding mitochondrial function in both the isolated organelles and intact cells. I have also carried out investigator initiated clinical research in obesity and diabetes and participate in multi-centered clinical trials as Iowa site PI.