Ralph DeFronzo

基本信息

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职业迁徙

个人简介

Dr. Ralph DeFronzo's major interests focus on the pathogenesis and treatment of type 2 diabetes mellitus and the central role of insulin resistance in the metabolic-cardiovascular cluster of disorders known collectively as the Insulin Resistance Syndrome. Using the euglycemic insulin clamp technique in combination with radioisotope turnover methodology, limb catheterization, indirect calorimetry and muscle biopsy, he has helped to define the biochemical and molecular disturbances responsible for insulin resistance and impaired glucose metabolism.

研究兴趣

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Pre-Prediabetes: Insulin Resistance is Associated with Cardiometabolic Risk in Non-obese Patients (STOP DIABETES)

John Armato,Ralph A. Defronzo,Muhammad Abdul-Ghani,Ron Ruby

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2024)

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278-OR: Single-Nucleus Multiomics Profiling Across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures

BENJAMIN LI,Arushi Varshney,ADELAIDE TOVAR,Nandini Manickam,Peter Orchard,Ralph A. DeFronzo,Luke Norton, Stephen C.J. Parker

Diabetesno. Supplement_1 (2024)

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Longitudinal Effects of Glucose-Lowering Medications on Β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: the GRADE Randomized Clinical Trial

Neda Rasouli,Naji Younes,Alokananda Ghosh,Jeanine Albu,Robert M. Cohen,Ralph A. DeFronzo, Elsa Diaz,Laure Sayyed Kassem,José A. Luchsinger,Janet B. McGill,William I. Sivitz,William V. Tamborlane,Kristina M. Utzschneider,Steven E. Kahn,J.P. Crandall, M.D. McKee, S. Behringer-Massera, J. Brown-Friday, E. Xhori, K. Ballentine-Cargill,S. Duran, H. Estrella, S. Gonzalez de la torre, J. Lukin,L.S. Phillips, E. Burgess,D. Olson, M. Rhee, P. Wilson, T.S. Raines,J. Boers,J. Costello, M. Maher-Albertelli, R. Mungara, L. Savoye, C.A. White, C. Gullett,L. Holloway, F. Morehead,S. Person, M. Sibymon, S. Tanukonda, C. Adams, A. Ross,A. Balasubramanyam,R. Gaba, E. Gonzalez Hattery, A. Ideozu, J. Jimenez, G. Montes, C. Wright,P. Hollander,E. Roe, A. Jackson, A. Smiley,P. Burt, L. Estrada, K. Chionh, F. Ismail-Beigi, C. Falck-Ytter,L. Sayyed Kassem, A. Sood, M. Tiktin, T. Kulow, C. Newman, K.A. Stancil, B. Cramer, J. Iacoboni, M.V. Kononets,C. Sanders, L. Tucker, A. Werner, A. Maxwell, G. McPhee,C. Patel, L. Colosimo, A. Krol,R. Goland, J. Pring, L. Alfano,P. Kringas, C. Hausheer, J. Tejada, K. Gumpel, A. Kirpitch, H. Schneier,J.B. Green, H. AbouAssi,R. Chatterjee,M.N. Feinglos, J. English Jones, S.A. Khan, J.B. Kimpel, R.P. Zimmer, M. Furst, B.M. Satterwhite, C.R. Thacker, K. Evans Kreider, C.N. Mariash,K.J. Mather, H.M. Ismail,A. Lteif,M. Mullen, T. Hamilton, N. Patel, G. Riera, M. Jackson, V. Pirics, D. Aguillar, D. Howard, S. Hurt,R. Bergenstal,A. Carlson, T. Martens, M. Johnson, R. Hill, J. Hyatt,C. Jensen, M. Madden, D. Martin, H. Willis, W. Konerza, S. Yang, K. Kleeberger, R. Passi, S. Fortmann,M. Herson, K. Mularski,H. Glauber,J. Prihoda, B. Ash, C. Carlson, P.A. Ramey, E. Schield, B. Torgrimson-Ojerio, K. Arnold, B. Kauffman, E. Panos, S. Sahnow,K. Bays, K. Berame, J. Cook, D. Ghioni, J. Gluth, K. Schell, J. Criscola, C. Friason, S. Jones, S. Nazarov, J. Barzilay,N. Rassouli, R. Puttnam, B. Ojoawo, R. Nelson, M. Curtis, B. Hollis, C. Sanders-Jones,K. Stokes, Z. El-Haqq, A. Kolli, T. Tran, D. Wexler,M.E. Larkin,J. Meigs, B. Chambers,A. Dushkin, G. Rocchio, M. Yepes,B. Steiner, H. Dulin, M. Cayford,K. Chu, A. DeManbey, M. Hillard, K. Martin, N. Thangthaeng, L. Gurry, R. Kochis, E. Raymond, V. Ripley,C. Stevens, J. Park,V. Aroda,A. Ghazi,M. Magee, A. Ressing, A. Loveland, M. Hamm, M. Hurtado, A. Kuhn, J. Leger, L. Manandhar, F. Mwicigi,O. Sanchez,T. Young, R. Garg, V. Lagari-Libhaber,H.J. Florez, W.M. Valencia, J. Marks, S. Casula, L. Oropesa-Gonzalez,L. Hue, A. Cuadot, R. Nieto-Martinez, A.K. Riccio Veliz,M. Gutt, Y.J. Kendal, B. Veciana,A. Ahmann, D. Aby-Daniel, F. Joarder, V. Morimoto, C. Sprague, D. Yamashita, N. Cady, N. Rivera-Eschright, P. Kirchhoff, B. Morales Gomez, J. Adducci, A. Goncharova, S.H. Hox, H. Petrovitch, M. Matwichyna, V. Jenkins, L. Broadwater, R.R. Ishii, N.O. Bermudez, D.S. Hsia,W.T. Cefalu,F.L. Greenway, C. Waguespack, E. King, G. Fry, A. Dragg, B. Gildersleeve, J. Arceneaux,N. Haynes, A. Thomassie, M. Pavlionis, B. Bourgeois, C. Hazlett,S. Mudaliar, R. Henry,S. Boeder,J. Pettus, E. Diaz, D. Garcia-Acosta, S. Maggs, C. DeLue, A. Stallings,E. Castro, S. Hernandez,J. Krakoff, J.M. Curtis, T. Killean, M. Khalid, E. Joshevama, K. Tsingine, T. Karshner,J. Albu,F.X. Pi-Sunyer, S. Frances,C. Maggio, E. Ellis, J. Bastawrose,X. Gong,M.A. Banerji,P. August, M. Lee, D. Lorber,N.M. Brown, D.H. Josephson, L.L. Thomas, M. Tsovian, A. Cherian, M.H. Jacobson, M.M. Mishko,M.S. Kirkman,J.B. Buse, J. Diner, J. Dostou, S. Machineni, L. Young, K. Bergamo, A. Goley, J. Kerr, J.F. Largay, S. Guarda, J. Cuffee, D. Culmer, R. Fraser, H. Almeida, S. Coffer, E. Debnam, L. Kiker,S. Morton, K. Josey,G. Fuller,W.T. Garvey,A.L. Cherrington, D. Dyer, M.C.R. Lawson,O. Griffith, A. Agne, S. McCullars,R.M. Cohen, J. Craig, M.C. Rogge,K. Burton,K. Kersey, C. Wilson,S. Lipp, M.B. Vonder Meulen,C. Adkins, T. Onadeko,N. Rasouli, C. Baker,E. Schroeder, M. Razzaghi, C. Lyon, R. Penaloza, C. Underkofler, R. Lorch, S. Douglass,S. Steiner,W.I. Sivitz,E. Cline, L.K. Knosp,J. McConnell, T. Lowe,W.H. Herman,R. Pop-Busui,M.H. Tan, C. Martin, A. Waltje,A. Katona, L. Goodhall, R. Eggleston, S. Kuo, S. Bojescu, S. Bule, N. Kessler, E. LaSalle, K. Whitley,E.R. Seaquist, A. Bantle, T. Harindhanavudhi, A. Kumar,B. Redmon,J. Bantle,M. Coe,M. Mech, A. Taddese, K. Lesne, S. Smith,C. Desouza, L. Kuechenmeister, V. Shivaswamy, S. Burbach, M.G. Rodriguez, K. Seipel, A. Alfred, A.L. Morales, J. Eggert, G. Lord, W. Taylor, R. Tillson,D.S. Schade, A. Adolphe,M. Burge,E. Duran-Valdez, J. Martinez, A. Bancroft, S. Kunkel, F. Ali Jamaleddin Ahmad, D. Hernandez McGinnis, B. Pucchetti, E. Scripsick, A. Zamorano,R.A. DeFronzo,E. Cersosimo,M. Abdul-Ghani,C. Triplitt, D. Juarez, R.I. Garza, H. Verastiqui,K. Wright,C. Puckett,P. Raskin, C. Rhee, S. Abraham, L.F. Jordan, S. Sao,L. Morton, O. Smith, L. Osornio Walker, L. Schnurr-Breen, R. Ayala, R.B. Kreymer, D. Sturgess,K.M. Utzschneider,S.E. Kahn, L. Alarcon-Casas Wright,E.J. Boyko, E.C. Tsai, D.L. Trence, S. Trikudanathan, B.N. Fattaleh, B.K. Montgomery, K.M. Atkinson, A. Kozedub, T. Concepcion, C. Moak, N. Prikhodko, S. Rhothisen,T.A. Elasy, S. Martin,L. Shackelford, R. Goidel, N. Hinkle, C. Lovell, J. Myers, J. Lipps Hogan,J.B. McGill, M. Salam, T. Schweiger,S. Kissel,C. Recklein, M.J. Clifton,W. Tamborlane, A. Camp, B. Gulanski,S.E. Inzucchi,K. Pham, M. Alguard,P. Gatcomb, K. Lessard, M. Perez, L. Iannone, E. Magenheimer, A. Montosa,J. Fradkin, H.B. Burch, A.A. Bremer,D.M. Nathan,J.M. Lachin, H. Krause-Steinrauf,N. Younes,I. Bebu, N. Butera, C.J. Buys, A. Fagan, Y. Gao,A. Ghosh, M.R. Gramzinski, S.D. Hall, E. Kazemi, E. Legowski, H. Liu, C. Suratt, M. Tripputi, A. Arey, M. Backman, J. Bethepu,C. Lund, P. Mangat Dhaliwal,P. McGee, E. Mesimer, L. Ngo,M. Steffes, J. Seegmiller, A. Saenger, V. Arends, D. Gabrielson,T. Conner, S. Warren, J. Day, J. Huminik, A. Scrymgeour,E.Z. Soliman, Y. Pokharel, Z.M. Zhang, C. Campbell, J. Hu, L. Keasler, S. Hensley, Y. Li, R. Mihalcea, D.J. Min, V. Perez-Rosas, L. Prosser, L. Resnicow,W. Ye, H. Shao, P. Zhang,J. Luchsinger, D. Sanchez, S. Assuras,E. Groessl, F. Sakha, H. Chong,N. Hillery, I. Abdouch,G. Bahtiyar, P. Brantley, F.E. Broyles, G. Canaris, P. Copeland, J.J. Craine, W.L. Fein,A. Gliwa,L. Hope, M.S. Lee, R. Meiners, V. Meiners, H. O’Neal, J.E. Park,A. Sacerdote, E. Sledge,L. Soni, J. Steppel-Reznik,A. Turchin

Diabetes Careno. 4 (2024): 580-588

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Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects