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The Carruthers lab seeks to understand survival strategies employed by microbial pathogens during infection. We use the protozoan Toxoplasma gondii(link is external) as a model pathogen because of its genetic and biochemical tractability, well-defined cellular structure, and the availability of excellent rodent models of disease. Toxoplasma replicates in a remarkable variety of cells and organs, causing encephalitis, pneumonia, myocarditis, ocular disease, and congenital birth defects during acute infection. While disease is seen in only a small fraction of the ~2 billion people infected worldwide, the diagnosis and treatment of toxoplasmosis are suboptimal and the disease remains a significant and neglected(link is external) public health problem. In people with healthy immune status, the parasite typically remains in a chronic, encysted state, but the infection can erupt when immune function is compromised such as individuals with HIV/AIDS, organ transplant recipients, or cancer patients undergoing chemotherapy.
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论文共 137 篇作者统计合作学者相似作者
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mBiono. 4 (2024): e0028324-e0028324
Pariyamon Thaprawat,Zhihai Zhang, Eric C Rentchler,Fengrong Wang, Shreya Chalasani,Christopher J Giuliano,Sebastian Lourido,Manlio Di Cristina,Daniel J Klionsky,Vern B Carruthers
Autophagy Reportsno. 1 (2024)
NATURE COMMUNICATIONSno. 1 (2024)
MSPHEREno. 1 (2024)
Halle C Frey, Xin Sun, Fatima Oudeif, Darleny L Corona, Zijun He,Taejoon Won,Tracy L Schultz,Vern B Carruthers,Amale Laouar,Yasmina Laouar
bioRxiv : the preprint server for biology (2024)
Hargobinder Kaur,Einar Olafsson,Rebekah Guevara,Joshua Mayoral, Phyllis Hanson,Louis Weiss,Vernon Carruthers
Journal of Biological Chemistryno. 3 (2024)
MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 1048-1048
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The EMBO journalno. 23 (2023): e113155-e113155
Patricia Silvia Romano,Takahiko Akematsu,Sébastien Besteiro,Annina Bindschedler,Vern B Carruthers,Zeinab Chahine,Isabelle Coppens,Albert Descoteaux,Thabata Lopes Alberto Duque,Cynthia Y He,Volker Heussler,Karine G Le Roch,Feng-Jun Li,Juliana Perrone Bezerra de Menezes,Rubem Figueiredo Sadok Menna-Barreto,Jeremy C Mottram,Jacqueline Schmuckli-Maurer,Boris Turk,Patricia Sampaio Tavares Veras,Betiana Nebai Salassa,María Cristina Vanrell
Autophagy reportsno. 1 (2023)
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#Papers: 137
#Citation: 9106
H-Index: 48
G-Index: 95
Sociability: 6
Diversity: 3
Activity: 11
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