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Trypanosoma brucei (锥形虫) causes African sleeping sickness in humans and Nagano in cattle, bringing huge economic burdens to many developing countries that can least afford it . Though largely neglected in the past, the studies of T. brucei and related pathogens have attracted great attentions in global health research in the recent years, including major funding support from the Bill and Melinda Gates Foundation.
As a model system, the single-celled T. brucei is one of the earliest divergent eukaryotic organisms studied in laboratories. Genomic databases of T. brucei and related species are complete. Development in advanced molecular genetics methods such as inducible expression and RNAi allows rapid characterization of protein functions. Furthermore, T. brucei has a simple cellular anatomy with a single copy of nucleus, mitochondrion, flagellum, and Golgi, suitable for fluorescence microscopic and electron microscopic studies. Duplication and segregation of these organelles take place in a strict temporal and spatial order, allowing rapid and reliable identification of cell cycle stages in an unsynchronized population. Using T. brucei as a model organism, we study the organization of cellular structures and the regulation of their co-ordinated duplication/segregation during cell cycle.
Trypanosoma brucei (锥形虫) causes African sleeping sickness in humans and Nagano in cattle, bringing huge economic burdens to many developing countries that can least afford it . Though largely neglected in the past, the studies of T. brucei and related pathogens have attracted great attentions in global health research in the recent years, including major funding support from the Bill and Melinda Gates Foundation.
As a model system, the single-celled T. brucei is one of the earliest divergent eukaryotic organisms studied in laboratories. Genomic databases of T. brucei and related species are complete. Development in advanced molecular genetics methods such as inducible expression and RNAi allows rapid characterization of protein functions. Furthermore, T. brucei has a simple cellular anatomy with a single copy of nucleus, mitochondrion, flagellum, and Golgi, suitable for fluorescence microscopic and electron microscopic studies. Duplication and segregation of these organelles take place in a strict temporal and spatial order, allowing rapid and reliable identification of cell cycle stages in an unsynchronized population. Using T. brucei as a model organism, we study the organization of cellular structures and the regulation of their co-ordinated duplication/segregation during cell cycle.
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论文共 64 篇作者统计合作学者相似作者
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SCIENCE ADVANCESno. 36 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Patricia Silvia Romano,Takahiko Akematsu,Sébastien Besteiro,Annina Bindschedler,Vern B Carruthers,Zeinab Chahine,Isabelle Coppens,Albert Descoteaux,Thabata Lopes Alberto Duque,Cynthia Y He,Volker Heussler,Karine G Le Roch,Feng-Jun Li,Juliana Perrone Bezerra de Menezes,Rubem Figueiredo Sadok Menna-Barreto,Jeremy C Mottram,Jacqueline Schmuckli-Maurer,Boris Turk,Patricia Sampaio Tavares Veras,Betiana Nebai Salassa,María Cristina Vanrell
Autophagy reportsno. 1 (2023)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
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#Papers: 64
#Citation: 2036
H-Index: 24
G-Index: 44
Sociability: 6
Diversity: 3
Activity: 5
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