Research overview
Fighting antibiotic resistance using drug combinations: We are developing software tools (e.g. INDIGO, MAGENTA) to design drug combinations with enhanced potency and reduced potential for developing resistance. We also study pathogen metabolism and pathogen-immune interactions to discover new synergistic antibiotics against M. tuberculosis, S. aureus and other pathogens.
Systems biology algorithms to understand metabolic regulation: Our lab is developing new modeling tools to simulate the activity of thousands of metabolic reactions in a human or microbial cell, giving us a unique systems perspective on metabolic regulation. We have applied the methods that we developed (e.g. PROM, DFA, GEMINI and ASTRIX) to understand microbial, stem-cell, cancer, and brain metabolism using omics datasets.