Robert D Pelletier - Schrodinger Inc.

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论文共 24 篇作者统计合作学者相似作者

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In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury

H. Rachel Lagiakos, Yefen Zou,Hideyuki Igawa,Eric Therrien,Morgan Lawrenz,Mitsunori Kato,Mats Svensson,Felicia Gray,Kristian Jensen,Markus K. Dahlgren,Robert D. Pelletier,Karen Dingley,Jeffrey A. Bell, Zhijian Liu, Yuansong Jiang, Hua Zhou,Robert J. Skene,Zhe Nie

Journal of Medicinal Chemistry (2024)

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Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an in Silico Enabled Drug Discovery Platform

Hideyuki Igawa, Zef A. Konst,Eric Therrien,Mee Shelley, Heidi Koldsø,Pieter H. Bos, Ana Negri, Andreas Verras, Jiaye Guo,Markus K. Dahlgren,Adam Levinson, Brendan T. Parr,Suresh E. Kurhade, Prashant Latthe, Rajesha Shetty, Sridhar Santhanakrishnan, Katherine Amberg-Johnson,Alan S. Futran,Christian Atsriku,Robert D. Pelletier

Journal of medicinal chemistryno. 24 (2024): 21811-21840

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Ubiquitin-specific Protease 7 Inhibitors Reveal a Differentiated Mechanism of P53-Driven Anti-Cancer Activity

Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce,Jeffrey A. Bell,Robert Pelletier,Takao Suzuki,Xianhai Huang,Heng Qian, Liping Fang,Li Xing,Zhaowu Xu,Stephen E. Kurtz,Jeffrey W. Tyner,Wayne Tang, Tao Guo,Karen Akinsanya, David Madge,Kristian K. Jensen

ISCIENCE（2024）

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Sgr-1505 is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile

Wu Yin,Min Ye,Netonia Marshall,Joanne Bl Tan, Evan Paull,Zhe Nie,MIchael Trzoss,Goran Krilov,Shulu Feng,Robert Pelletier,Jeff Bell,Peter Skrdla,David Calkins, MaryBeth Grimes,D. Hamish Wright,Karen Akinsanya

BLOOD（2023）

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Improved Methods for the Detection of Heme and Protoporphyrin IX Adducts and Quantification of Heme B from Cytochrome P450 Containing Systems

Robert D. Pelletier,Allan E. Rettie,John P. Kowalski

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES（2023）

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Selective Deuteration of Bupropion Slows Epimerization and Reduces Metabolism

Yuanyuan Shi,Jean Dinh,Robert Pelletier,Brianne Raccor, Naeem Yusuff,Adam Morgan,Scott Harbeson,Vinita Uttamsingh,Rheem Totah

SSRN Electronic Journal（2022）

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Discovery of potent, selective, and orally available WEE1 inhibitors that demonstrate increased DNA damage and mitosis in tumor cells leading to tumor regression in vivo

Shaoxian Sun, Sarah Silvergleid,Aleksey I. Gerasyuto,Jiashi Wang,Robert D. Pelletier,Andrew Placzek,Jennifer L. Knight, Anthony Clark,Hamish Wright,Wu Yin,Jackson Chief Elk,Jeff Bell,Pieter H. Bos,Nicholas A. Boyles,Eric Therrien,Kristian Jensen,Karen Akinsanya

CANCER RESEARCHno. 12 (2022)

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Abstract 2570: Discovery of Potent, Selective, and Orally Available WEE1 Inhibitors That Demonstrate Increased DNA Damage and Mitosis in Tumor Cells Leading to Tumor Regression in Vivo

Cancer Researchno. 12_Supplement (2022): 2570-2570

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Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies

Blood（2021）

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Pharmacokinetics, Metabolism and Off-Target Effects in the Rat of 8-[(1H- Benzotriazol-1-yl)amino]octanoic Acid, a Selective Inhibitor of Human Cytochrome P450 4Z1: Β-Oxidation As a Potential Augmenting Pathway for Inhibition

John P. Kowalski,Robert D. Pelletier,Matthew G. McDonald,Edward J. Kelly,Allan E. Rettie

Xenobiotica（2021）

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