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    • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Journal

    Papers
    Development and Validation of A Lc-Ms/Ms Method for the Determination of the Novel Oral 1,14 Substituted Taxane Derivatives, Idn 5738 and Idn 5839, in Mouse Plasma and Its Application to the Pharmacokinetic Study
    Elena Marangon,Cristiano Falcioni,Carla Manzotti,Gabriele Fontana,Maurizio D'Incalci,Massimo Zucchetti
    Journal of Chromatography B（2009）
    Two LC-ESI-MS and CID-MS/MS methods were developed and validated for pharmacokinetic studies of the novel oral taxane derivatives IDN 5738 and IDN 5839, used for preclinical evaluation in mice. The analysis requires 100muL of plasma sample, involves the addition of an internal st...
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    Simultaneous Quantification of the Glucagon-Like Peptide-1 (GLP-1) and Cholecystokinin (CCK) Receptor Agonists in Rodent Plasma by On-Line Solid Phase Extraction and LC–MS/MS
    Yan Wang,Jonathan D. Roth,Steven W. Taylor
    Journal of Chromatography B（2014）
    Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) and the cholecystokinin-1 receptor (CCK1-R) have therapeutic potential because of their marked anorexigenic and weight lowering effects. Furthermore, recent studies in rodents have shown that co-administration of t...
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    Determination of Rhodamine 123 in cell lysate by HPLC with visible wavelength detection
    Tahira Iqbal,Minori Kinjo,Thomas C Dowling
    Journal of Chromatography B（2005）
    Rhodamine 123 (R123) is widely used to quantify P-glycoprotein (P-GP) functional efflux activity in vitro. We developed a rapid and specific high-performance liquid chromatography (HPLC) method to quantify Rhodamine 123 for use in experimental cell culture studies. The R123 stand...
    Cited25Views0
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    Monolithic Capillary Columns for Liquid Chromatography-Electrospray Ionization Mass Spectrometry in Proteomic and Genomic Research
    W Walcher,H Oberacher,S Troiani,G Holzl,P Oefner,L Zolla,Cg Huber
    Journal of Chromatography B（2002）
    Peptides, proteins, single-stranded oligonucleotides, and double-stranded DNA fragments were separated with high resolution in micropellicular, monolithic capillary columns prepared by in situ radical copolymerization of styrene and divinylbenzene. Miniaturized chromatography bot...
    Cited101Views0
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    A Comprehensive Method for the Quantification of the Non-Oxidative Pentose Phosphate Pathway Intermediates in Saccharomyces Cerevisiae by GC–IDMS
    Chiara Cipollina,Angela Ten Pierick,Andre B. Canelas,Reza M. Seifar,Antonius J. A. Van Maris,Jan C. Van Dam,Joseph J. Heijnen
    Journal of Chromatography B（2009）
    A gas chromatography isotope dilution mass spectrometry (GC–IDMS) method was developed for the quantification of the metabolites of the non-oxidative part of pentose phosphate pathway (PPP). A mid-polar GC column (Zebron ZB-AAA, 10m, film composition 50% phenyl 50% dimethyl polys...
    Cited79Views0
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    Multivariate Analysis of Fatty Acids in Spores of Higher Basidiomycetes: a New Method for Chemotaxonomical Classification of Fungi
    I Brondz,K Hoiland,D Ekeberg
    Journal of Chromatography B（2003）
    The aim of the present work was to study the possibility of using the fatty acid content in the basidiospores as a taxonomic tool. Basidiospores of Armillaria borealis, Amanita muscaria, Agaricus sylvicola, Hypholoma capnoides, Cortinarius nemorensis and Russula delica were used....
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    Simultaneous Determination of Vigabatrin and Amino Acid Neurotransmitters in Brain Microdialysates by Capillary Electrophoresis with Laser-Induced Fluorescence Detection
    N Benturquia,S Parrot,V Sauvinet,B Renaud,L Denoroy
    Journal of Chromatography B（2004）
    Capillary electrophoresis with laser-induced fluorescence detection (CE-LIFD) coupled to in vivo microdialysis sampling was used in order to monitor simultaneously a drug and several neurotransmitters in the brain extracellular fluid. Determination of the antiepileptic drug vigab...
    Cited58Views0
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    Validated Assay for the Determination of Markers of Illicit Heroin in Urine Samples for the Control of Patients in a Heroin Prescription Program
    F Musshoff,J Trafkowski,B Madea
    Journal of Chromatography B（2004）
    A fully validated procedure for the simultaneous determination of morphine (MOR), morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), 6-acetylmorphine (6AM), codeine (COD), codeine-6-glucuronide (C6G), acetylcodeine (AC), noscapine (NOS) and papaverine (PAP) based on liqu...
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    Simultaneous Detection of Arginine, Asymmetric Dimethylarginine, Symmetric Dimethylarginine and Citrulline in Human Plasma and Urine Applying Liquid Chromatography–mass Spectrometry with Very Straightforward Sample Preparation
    J Martens-Lobenhoffer,SM Bode-Boger
    Journal of Chromatography B（2003）
    Nitric oxide (NO) is synthesized by NO synthase from L-arginine, which can be competitively blocked by endogenous inhibitors such as asymmetric dimethylarginine (ADMA), but not by symmetric dimethylarginine (SDMA). ADMA is degraded by dimethylarginine dimethylaminohydrolase (DDAH...
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    Strong Electrostatic Repulsive Interaction Used for Fast and Effective Alkaloid Enrichment from Plants
    Nana Du,Wei Si,Yanfang Liu,Zhimou Guo,Weijia Zhou,Han Zhou,Xinmiao Liang,Chaoran Wang
    Journal of Chromatography B（2018）
    Since the content of alkaloids is usually low in plants and they are easily co-eluted with other constituents, enrichment of alkaloids is essential in the discovery of bioactive lead compounds from natural products. In this paper, an easy SPE enrichment method was developed in a ...
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    Simultaneous High-Performance Liquid Chromatographic Analysis of Pregabalin, Gabapentin and Vigabatrin in Human Serum by Precolumn Derivatization with O-Phtaldialdehyde and Fluorescence Detection
    TAC Vermeij,PM Edelbroek
    Journal of Chromatography B（2004）
    A rapid, simple and robust method is presented for the simultaneous determination of the gamma-amino-n-butyric acid (GABA) derivatives pregabalin (PGB), gabapentin (GBP) and vigabatrin (VGB) in human serum by high-performance liquid chromatography (HPLC). Serum is deproteinized w...
    Cited125Views0
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    Metabolomics Study on the Antitumor Effect of Marine Natural Compound Flexibilide in HCT-116 Colon Cancer Cell Line
    Dan Gao,Yini Wang,Weiyi Xie,Ti Yang,Yuyang Jiang,Yuewei Guo,Jin Guan,Hongxia Liu
    Journal of Chromatography B（2016）
    A marine natural compound flexibilide isolated from the soft coral Sinularia flexibilis has been found to have antitumor activity. However, its pharmacological mechanism on tumor cells has not been studied. Herein, an ultra-performance liquid chromatography coupled to quadrupole ...
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    A Simple and Sensitive Assay for Determining Plasma Tipranavir Concentration in the Clinical Setting by New HPLC Method
    Antonio D'Avolio,Mauro Sciandra,Marco Siccardi,Lorena Baietto,Daniel Gonzalez de Requena,Stefano Bonora,Giovanni Di Perri
    Journal of Chromatography B（2006）
    A simple method for the quantification of tipranavir, the first non-peptidic HIV protease inhibitor, was developed and validated. Quinoxaline, as internal standard, was added to 50 microl of plasma before a liquid-liquid extraction by 600 microl of protein precipitation solution....
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    Gas Chromatographic-Mass Spectrometric Analysis of Residual Solvent Trapped into Illicit Cocaine Exhibits Using Head-Space Solid-Phase Microextraction
    M Chiarotti,R Marsili,A Moreda-Pineiro
    Journal of Chromatography B（2002）
    The analysis of solvent residues trapped into crystals of illicit drugs provides useful evidence for monitoring current use trend in the chemical underground, and is also a suitable tool to achieve the complete chemical characterisation of street drugs for comparative examination...
    Cited28Views0
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    GC–MS Analysis of Bisphenol A in Human Placental and Fetal Liver Samples
    Jie Zhang,Gerard M. Cooke,Ivan H. A. Curran,Cynthia G. Goodyer,Xu-Liang Cao
    Journal of Chromatography B（2011）
    A method based on extraction with acetonitrile, followed by solid-phase extraction, derivatization with acetic anhydride, and isotope dilution gas chromatography–mass spectrometry (GC–MS) analysis was applied to determine levels of free and conjugated BPA in human tissues. β-Gluc...
    Cited88Views0
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    Quantification of 4 Antidepressants and a Metabolite by LC–MS for Therapeutic Drug Monitoring
    Eva Choong,Serge Rudaz,Astrid Kottelat,Sophie Haldemann,Davy Guillarme,Jean-Luc Veuthey,Chin B. Eap
    Journal of Chromatography B（2011）
    A liquid chromatography method coupled to mass spectrometry was developed for the quantification of bupropion, its metabolite hydroxy-bupropion, moclobemide, reboxetine and trazodone in human plasma. The validation of the analytical procedure was assessed according to Société Fra...
    Cited27Views0
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    Analysis of Agaritine in Mushrooms and in Agaritine-Administered Mice Using Liquid Chromatography-Tandem Mass Spectrometry
    K Kondo,A Watanabe,Y Iwanaga,I Abe,H Tanaka,MH Nagaoka,H Akiyama,T Maitani
    Journal of Chromatography B（2006）
    A sensitive and specific method for quantifying a genotoxic hydrazine, agaritine, has been developed using liquid chromatography-electrospray ionization tandem mass spectrometry (MS). Synthetic agaritine was structurally assigned by (1)H, (13)C and two-dimensional nuclear magneti...
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    Comparison of Liquid Chromatography with Fluorescence Detection to Liquid Chromatography–mass Spectrometry for the Determination of Fluoxetine and Norfluoxetine in Human Plasma
    I Kovacevic,B Miljkovic,D Jovanovic,M Prostran
    Journal of Chromatography B（2005）
    A comparison study on fluoxetine (FL) and norfluoxetine (NORFL) quantitation in human plasma was carried out between the recently developed liquid chromatographic method with fluorescence detection (LC-FLD) and an earlier established liquid chromatography-mass spectrometry (LC-MS...
    Cited49Views0
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