As a clinical trialist with interest and expertise in large-scale, impactful clinical trials, Dr. Swartz been involved in field-changing studies, including the ESCAPE trial (demonstrating effectiveness of endovascular therapy for stroke), ESCAPE NA-1 trial (showing that neuroprotection may be possible in hyperacute stroke). He is the co-PI of the AcT trial (Alteplase compared to Tenecteplase) a CIHR-funded, pragmatic registry embedded RCT, and leads a cognitive outcome sub-study (AcT-Cog). Dr. Swartz is also the lead neurologist on the steering committee for the ROMA trial (an international cardiac surgery trial comparing outcomes with different surgical grafting techniques) and co-PI for the cognitive outcome sub-study (ROMA-Cog).