We use transgenic animal models, clinical samples, circadian time series -omics, quantitative live imaging and machine learning algorithms to investigate the roles of circadian clocks in ageing and age-related diseases. Underpinning mechanisms identified will be targeted by pharmacological and other non-invasive approaches to slow down tissue degeneration and promote repair. We are also interested in a "circadian medicine" approach to tailor existing therapies according to the internal body clocks for better clinical outcomes.