Research in our lab is focused on the generation of functional tissue from somatic and pluripotent stem cells. Our quantitative, technology-driven approach strives to gain new insights into fundamental mechanisms that control stem cell fate and to develop robust technologies for the propagation of stem cells and their derivatives. Our primary focus is on applying these concepts to the hematopoietic system and differentiation of blood cell lineages. Our work is accomplished through 4 integrated research pillars: (1) Multi-scale simulation of human tissue- and organo-genesis, (2) Synthetic control of cell fate and function, (3) Cell niche engineering, and (4) Cellular therapeutics.