At Yale she continued her studies on CD8ab, a cell surface protein that functions as a co-receptor with the T Cell receptor on CD8 killer T cells. Her lab characterized the expression and functional differences of four isoforms of the human CD8b protein that exist in humans and great apes but not mice. They are differentially expressed in naive T cells, activated T cells, and memory T cells and they show differences in signal transduction and modification by ubiquitination. More recently she is studying how to enhance killing of human lung cancer tumors that have lost expression of HLA class I and are no longer killed by CD8 T killer cells.