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个人简介
The research activity concerns the study of the molecular mechanisms that regulate cell cycle, signal transduction and cell growth, with a focus on energetic metabolism and its dysfunctions linked to human diseases. The main topics of research are listed below. 1) Metabolism has been studied using different cellular systems also through systems biology approaches. Through proteomics, metabolomics and metabolic flux analyses, a new function of the AMP-activated protein kinase (AMPK), the main regulator of cellular energy homeostasis, was identified as a repressor of mitochondrial respiration and pyruvate entry into mitochondria in the unicellular organism S. cerevisiae. The metabolism of methionine in hepatocellular carcinoma cell lines was also evaluated. An integrated proteomics and metabolomics analysis indicated that methionine metabolism and AMPK activity play a crucial function in TCA regulation, cell growth and migration, showing a synergistic role in reducing liver cancer progression at least in vitro. 2) AMPK and the target of rapamycin complex 1 (TORC1) are central kinase modules of two opposing signaling pathways that control eukaryotic cell growth and metabolism in response to the availability of energy and nutrients. Accordingly, energy depletion activates AMPK to inhibit growth, while nutrients and high energy levels activate TORC1 to promote growth. We showed that AMPK temporally maintains TORC1 inactive in glucose-starved cells and a novel feedback regulation of AMPK activity is actually under investigation. 3) Muti-omics analysis identified sex-specific AD hallmarks in human hippocampus, also highlighting a strong modulation of serine metabolism. 4) Studies have also been focused on understanding the effects of plant-derived bioactive compounds on protein aggregation responsible for neurodegeneration.
Referee for national and international agencies including: MIUR (Futuro in Ricerca 2010 e 2013); MIUR (VQR 2004-2010 e VQR 2011-2014, GEV 05 e GEV 06); University of Verona (Joint Projects 2012 e 2015); Babraham Institute, Cambridge.
Referee for scientific journals including: Oncogene, Cellular and Molecular Biology Letters, Molecular Biosystems, Medicinal Chemistry Communication, BMC Cancer, European Journal of Medicinal Chemistry, Biochimica et Biophysica Acta - General Subjects, Current Genetics, FEMS Yeast Research, FEMS Microbiology Letters, Yeast, Molecular and Cellular Biochemistry, Current Bioactive Compounds, Cell Systems, Molecules, OMICS, Molecular OMICS, Journal of Visualized Experiments (JoVE), Microbial Cell, Plos Genetics.
-Editor of Dataset Papers in Science Cell Biology, Hindawi Publishing Corporation, from 2013 to 2017 and Microbial Cell (Cell Physiology and Cell Signaling), Shared Science Publishers from 2017.
-Member of the Italian Society of Biochemistry (SIB).
Oral presentation at national and international conferences (from 2015)
-September 2015: 27th International Conference on Yeast Genetics and Molecular Biology. "Glucose and amino acids addiction is a typical hallmark of Snf1/AMPK deficient cells" (W4: Growth Control and Metabolism), Levico Terme, Trento, Italy.
-September 2015: 58th National Meeting of the Italian Society of Biochemistry and Molecular Biology. "Glucose and Amino Acids Addiction Is a Typical Hallmark of Snf1/AMPK-Deficient Cells” (Symposium: Metabolism and Computational Biology), Urbino, Italy.
-September 2016: XIV FISV Congress (Italian Federation of Life Sciences), "Methionine metabolism imbalance in AMPK-deficient yeast models" (Session: Nutrition Biochemistry). Università La Sapienza, Roma.
-October 2016: invited at the Institute National des Sciences Appliquèes by Prof. Jean Marie Francois. "Snf1/AMPK in budding yeast: not only a guardian of energy homeostasis in nutritional deprivation", Tolouse, France.
-April 2017: Workshop of the SIB group Computational and Systems Biology, “Proteomics and integrative omic approaches for understanding the control of energy homeostasis”. Bologna, Italy.
-May 2017: 12th International Meeting on Yeast Apoptosis. “Snf1/AMPK regulates metabolism and autophagy in a methionine-dependent manner” (Session 5: Autophagy/Mitophagy), Bari, Italy.
-June 2019: 1st International Conference on Neuroprotection by Drugs, Nutraceuticals and Physical Activity, “Neuroprotective Properties of Standardized Extracts from Vigna unguiculata in yeast models of neurodegeneration” (Session: Neuroprotection by Nutraceuticals), Rimini, Italy.
-December 2021: 2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity, “Neuroprotective Properties of Extracts from G. frondosa and H. erinaceus in models of neurodegeneration” (Session: Dietary supplements, nutraceuticals, and functional foods in neuroprotection), Virtual edition.
Teaching
Cellular biochemistry, Laboratory of biochemistry and Functions and dynamics of intracellular proteins, Biochemistry of natural compounds.
研究兴趣
论文共 80 篇作者统计合作学者相似作者
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Microbial Cell (2024): 143-154
Teresa Docimo,Rita Celano, Alessia Lambiase,Rosa Di Sanzo, Simona Serio,Valentina Santoro,Paola Coccetti,Mariateresa Russo,Luca Rastrelli,Anna Lisa Piccinelli
Antioxidantsno. 1 (2024): 93-93
Marco Caligaris,Raffaele Nicastro,Zehan Hu,Farida Tripodi,Johannes Erwin Hummel, Benjamin Pillet, Marie-Anne Deprez,Joris Winderickx, Sabine Rospert,Paola Coccetti,Jorn Dengjel,Claudio De Virgilio
ELIFE (2023)
crossref(2023)
FEBS JOURNALno. 18 (2023): 4440-4464
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作者统计
#Papers: 80
#Citation: 1867
H-Index: 27
G-Index: 42
Sociability: 6
Diversity: 3
Activity: 20
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