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All living cells are capable of exiting the normal cell cycle (proliferating state) and entering an alternative (resting) state termed quiescence or G0. Despite the fact that most eukaryotic cells - whether they exist as single cells or as part of a multicellular organism - spend most of their life in a quiescent state, relatively little is known about the regulatory mechanisms that control entry into or exit from such a state. The available body of data, nevertheless, indicates that disruption of G0-entry/exit control mechanisms is often associated with either cellular transformation (particularly in multicellular organisms), or dramatically reduced life span (of unicellular organisms). In this context, we study the mechanisms controlling entry into, survival in, and exit from quiescence in the unicellular, eukaryotic model organism S. cerevisiae. So far, several studies (including ours) have uncovered that the nutrient-regulated hub TORC1 orchestrates both entry into and exit from G0. Our research is therefore specifically focused on the elucidation of both the mechanisms that regulate TORC1 activity and the nature of the effectors that are regulated by TORC1.
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Papers共 139 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF CELL BIOLOGYno. 6 (2024)
microPublication biology (2024)
Sebastian J. Hofer,Ioanna Daskalaki,Martina Bergmann,Jasna Friscic,Andreas Zimmermann, Melanie I. Mueller,Mahmoud Abdellatif,Raffaele Nicastro, Sarah Masser,Sylvere Durand, Alexander Nartey, Mara Waltenstorfer, Sarah Enzenhofer, Isabella Faimann, Verena Gschiel,Thomas Bajaj, Christine Niemeyer,Ilias Gkikas,Lukas Pein,Giulia Cerrato,Hui Pan,YongTian Liang,Jelena Tadic, Andrea Jerkovic,Fanny Aprahamian,Christine E. Robbins,Nitharsshini Nirmalathasan,Hansjoerg Habisch, Elisabeth Annerer,Frederik Dethloff,Michael Stumpe,Franziska Grundler,Francoise Wilhelmi de Toledo,Daniel E. Heinz,Daniela A. Koppold, Anika Rajput Khokhar,Andreas Michalsen,Norbert J. Tripolt,Harald Sourij,Thomas R. Pieber,Rafael de Cabo,Mark A. McCormick,Christoph Magnes,Oliver Kepp,Joern Dengjel,Stephan J. Sigrist,Nils C. Gassen,Simon Sedej,Tobias Madl,Claudio De Virgilio,Ulrich Stelzl,Markus H. Hoffmann,Tobias Eisenberg,Nektarios Tavernarakis,Kroemer Guido,Frank Madeo
NATURE CELL BIOLOGYno. 9 (2024)
Irene Sambri,Marco Ferniani,Giulia Campostrini,Marialuisa Testa,Viviana Meraviglia,Mariana E. G. de Araujo,Ladislav Dokládal,Claudia Vilardo,Jlenia Monfregola,Nicolina Zampelli,Francesca Del Vecchio Blanco,Annalaura Torella,Carolina Ruosi,Simona Fecarotta,Giancarlo Parenti,Leopoldo Staiano,Milena Bellin,Lukas A. Huber,Claudio De Virgilio,Francesco Trepiccione,Vincenzo Nigro,Andrea Ballabio
Journal of Fungino. 8 (2023): 787
crossref(2023)
Journal of Cell Scienceno. 12 (2023)
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Author Statistics
#Papers: 139
#Citation: 9585
H-Index: 49
G-Index: 95
Sociability: 6
Diversity: 3
Activity: 53
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