基本信息
浏览量:5
职业迁徙
个人简介
All living cells are capable of exiting the normal cell cycle (proliferating state) and entering an alternative (resting) state termed quiescence or G0. Despite the fact that most eukaryotic cells - whether they exist as single cells or as part of a multicellular organism - spend most of their life in a quiescent state, relatively little is known about the regulatory mechanisms that control entry into or exit from such a state. The available body of data, nevertheless, indicates that disruption of G0-entry/exit control mechanisms is often associated with either cellular transformation (particularly in multicellular organisms), or dramatically reduced life span (of unicellular organisms). In this context, we study the mechanisms controlling entry into, survival in, and exit from quiescence in the unicellular, eukaryotic model organism S. cerevisiae. So far, several studies (including ours) have uncovered that the nutrient-regulated hub TORC1 orchestrates both entry into and exit from G0. Our research is therefore specifically focused on the elucidation of both the mechanisms that regulate TORC1 activity and the nature of the effectors that are regulated by TORC1.
研究兴趣
论文共 125 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF CELL BIOLOGYno. 6 (2024)
microPublication biology (2024)
Sebastian J. Hofer,Ioanna Daskalaki,Martina Bergmann,Jasna Friscic,Andreas Zimmermann, Melanie I. Mueller,Mahmoud Abdellatif,Raffaele Nicastro, Sarah Masser,Sylvere Durand, Alexander Nartey, Mara Waltenstorfer, Sarah Enzenhofer, Isabella Faimann, Verena Gschiel,Thomas Bajaj, Christine Niemeyer,Ilias Gkikas,Lukas Pein,Giulia Cerrato,Hui Pan,YongTian Liang,Jelena Tadic, Andrea Jerkovic,Fanny Aprahamian,Christine E. Robbins,Nitharsshini Nirmalathasan,Hansjoerg Habisch, Elisabeth Annerer,Frederik Dethloff,Michael Stumpe,Franziska Grundler,Francoise Wilhelmi de Toledo,Daniel E. Heinz,Daniela A. Koppold, Anika Rajput Khokhar,Andreas Michalsen,Norbert J. Tripolt,Harald Sourij,Thomas R. Pieber,Rafael de Cabo,Mark A. McCormick,Christoph Magnes,Oliver Kepp,Joern Dengjel,Stephan J. Sigrist,Nils C. Gassen,Simon Sedej,Tobias Madl,Claudio De Virgilio,Ulrich Stelzl,Markus H. Hoffmann,Tobias Eisenberg,Nektarios Tavernarakis,Kroemer Guido,Frank Madeo
NATURE CELL BIOLOGY (2024)
Irene Sambri,Marco Ferniani,Giulia Campostrini,Marialuisa Testa,Viviana Meraviglia,Mariana E. G. de Araujo,Ladislav Dokládal,Claudia Vilardo,Jlenia Monfregola,Nicolina Zampelli,Francesca Del Vecchio Blanco,Annalaura Torella,Carolina Ruosi,Simona Fecarotta,Giancarlo Parenti,Leopoldo Staiano,Milena Bellin,Lukas A. Huber,Claudio De Virgilio,Francesco Trepiccione,Vincenzo Nigro,Andrea Ballabio
Journal of Fungino. 8 (2023): 787
crossref(2023)
Journal of Cell Scienceno. 12 (2023)
加载更多
作者统计
#Papers: 126
#Citation: 9695
H-Index: 49
G-Index: 98
Sociability: 6
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn