基本信息
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职业迁徙
个人简介
Date of birth
18 august 1961
Degrees
Chemistry degree cum laude, University of Modena, 1985
Ph.D. in Chemistry, University of Parma, 1992
Position held
Associate Professor of Physical Chemistry, University of Modena and Reggio Emilia, Faculty of Science, 2003-present
Researcher (Physical Chemistry), University of Modena and Reggio Emilia, Faculty of Science, 1992-2003
Publications
Prof. Marco Borsari is co-author of 124 articles in peer-reviewed international journals, of the entry "Cadmium: Inorganic and Coordination Chemistry" in Encyclopedia of Inorganic Chemistry (Wiley, New York 1994, 2006), as well as of some reviews.
Scientific activity
The scientific activity of Marco Borsari is mainly devoted to the molecular electrochemistry and bioelectrochemistry, in particular to the investigation of the redox and functional properties of electron transfer proteins and redox enzymes. He improved experimental techniques to direct (through suitable functionalized surfaces) and spectroelectrochemical characterization of the electron transfer properties of biopolymers. He gained experience in the characterization of the redox properties of cytochromes , blue copper proteins, iron-sulfur proteins, superoxide-dismutases and peroxidases. He investigate topics joined to the analysis of the redox thermodynamic parameters to understand the molecular determinants of the E°’ value and to characterize the aspects of the chemistry of these proteins in solution.
This problem is tackled with a thermodynamic approach by analysis of the enthalpic and entropic contributions to the free energy change involved in the electron transfer process and trying to correlate them to:
- the features of the first coordination sphere of the metal center
- the inherent coordinative properties of the metal site
- the electrostatic interactions of the metal center with the protein matrix and the solvent
- the general ionic strength effects and specific protein-ion binding
- the differences in protein flexibility and solvation properties of the two redox states.
Site-directed mutagenesis is exploited to create suitable protein variants to probe for the above effects and computational techniques are used to analyze the changes induced by the point mutation in molecular properties. The objective is the definition of quantitative relationships between the alteration in molecular properties induced by point mutations and variation of the thermodynamic parameters measured electrochemically. This quantitative structure-property relationships (QSPR) approach would in principle allow attainment of models for the rationalization and interpretation of the observed behaviors on molecular bases, with good predictive ability.
Fields of interest are:
- the properties of monolayers formed by cytochromes and cupredoxins immobilized on SAMs and comparison of the reactivity (reduction potential, electron transfer efficiency, conformational equilibria and catalytic properties) with that of the corresponding free diffusing protein. This information is a necessary step for the rational design of ET protein-based bio-molecular devices;
- the thermodynamic influence of solvent reorganization within the hydration sphere of ET metallo-proteins, associated with enthalpy/entropy compensation phenomena;
- the molecular factors that control the thermodynamics of conformational equilibria in ET metalloproteins involving changes in metal coordination, with particular reference to the alkaline transition in mitochondrial and bacterial cytochromes c and the acid transition in blue copper proteins;
- the determinants of the reduction potential of redox metalloenzymes (such as plant peroxidases or multi-copper oxidases).
Marco Borsari currently collaborates with several Italian and foreign scientists.
研究兴趣
论文共 208 篇作者统计合作学者相似作者
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CELL REPORTS PHYSICAL SCIENCEno. 8 (2024)
ChemElectroChemno. 7 (2024): n/a-n/a
JOURNAL OF INORGANIC BIOCHEMISTRY (2024)
CHEMISTRY-A EUROPEAN JOURNALno. 55 (2023)
INORGANIC CHEMISTRY FRONTIERSno. 1 (2023): 186-195
ACS Applied Materials & Interfaces (2023)
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作者统计
#Papers: 209
#Citation: 4440
H-Index: 37
G-Index: 55
Sociability: 6
Diversity: 3
Activity: 41
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