Louise Cadzow - Dept Quantitat Biosci, Merck & Co Inc

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Pan-cancer Analysis of Homologous Recombination Deficiency in Cell Lines

Anne E Dodson,Sol Shenker,Pamela Sullivan, Sumeet U Nayak,Chris Middleton,Michael McGuire, Edmond Chipumuro,Yuji Mishina,Erica R Tobin,Louise Cadzow,Andrew A Wylie, Dipen Sangurdekar

Cancer Research Communications (2024)

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Rational Design of a SOCS1-edited Tumor-Infiltrating Lymphocyte Therapy Using CRISPR/Cas9 Screens

Michael R. Schlabach,Sharon Lin, Zachary R. Collester,Christopher Wrocklage,Sol Shenker,Conor Calnan,Tianlei Xu,Hugh S. Gannon,Leila J. Williams, Frank Thompson, Paul R. Dunbar,Robert A. Lamothe,Tracy E. Garrett,Nicholas Colletti,Anja F. Hohmann,Noah J. Tubo,Caroline P. Bullock,Isabelle Le Mercier,Katri Sofjan,Jason J. Merkin,Sean Keegan,Gregory V. Kryukov, Caroline Dugopolski,Frank Stegmeier,Karrie Wong,Fiona A. Sharp,Louise Cadzow,Micah J. Benson

biorxiv（2023）

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Supplementary Data from Reverse Translating Molecular Determinants of Anti–Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models

Peter Georgiev,Eric S. Muise,Douglas E. Linn,Marlene C. Hinton,Yun Wang,Mingmei Cai,Louise Cadzow, Douglas C. Wilson,Selvakumar Sukumar,Michael Caniga, Lan Chen, Hui Xiao,Jennifer H. Yearley,Venkataraman Sriram, Michael Nebozhyn,Manjiri Sathe,Wendy M. Blumenschein, Kimberly S. Kerr,Heather A. Hirsch,Sarah Javaid,Aleksandra K. Olow,Lily Y. Moy,Derek Y. Chiang,Andrey Loboda, Razvan Cristescu,Svetlana Sadekova, Brian J. Long,Terrill K. McClanahan,Elaine M. Pinheiro

openalex（2023）

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KSQ-4279, a First-in-class USP1 Inhibitor Shows Strong Combination Activity in BRCA Mutant Cancers with Intrinsic or Acquired Resistance to PARP Inhibitors

Erica Tobin,Pamela Sullivan,Morgan Murray,Hugh Gannon,Anne Dodson,Sol Shenker,Frank Stegmeier,Andrew Wylie,Louise Cadzow

European journal of cancer（2022）

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Abstract ND01: KSQ-4279: A First-in-class USP1 Inhibitor for the Treatment of Cancers with Homologous Recombination Deficiencies

Louise Cadzow,Erica Tobin,Pamela Sullivan,Sol Shenker,Sumeet Nayak,Janid Ali,Hugh Gannon,Anne Dodson,Paula Grasberger,Alyssa Carlson,Michael McGuire, Jehrod Brenneman, Hanlan Liu,Andrew Olaharski,Kerstin Sinkevicius, Jeff Hixon, Elsa Krall,Mike Schlabach, Matt Goulet, Jeremy Wilt, Patricia Harris,Frank Stegmeier,Andrew Wylie

Cancer researchno. 12_Supplement (2022): ND01-ND01

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Abstract 1337: Functional Genomic Characterization of the USP1 Inhibitor KSQ-4279 Reveals a Distinct Mechanism of Action and Resistance Profile Relative to Other DDR Targeting Drugs

Stephen H. Shenker,Hugh Gannon,Alyssa Carlson,Paula Grasberger,Pamela Sullivan,Chris Middleton,Anne E. Dodson,Caroline Bullock,Michael H. McGuire,Erica Tobin,Kerstin W. Sinkevicius,Mike Schlabach,Frank Stegmeier,Louise Cadzow,Andrew Wylie

Cancer research（2021）

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186 Development of KSQ-001, an Engineered TIL (etil) Therapy for Solid Tumors Through CRISPR/Cas9-mediated Editing of SOCS1

Karrie Wong,Sharon Lin,Christopher Wrocklage,Katri Sofjan,Leila Williams,Mallory Brady,Nicholas Colletti,Noah Tubo,Hugh Gannon, Robert LaMothe,Tianlei Xu, Tracy VandenBerg,Sol Shenker, Caroline Dugopolski,Frank Stegmeier,Louise Cadzow,Michael Schlabach,Micah Benson

Regular and Young Investigator Award Abstracts（2021）

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204 KSQ-004: Unbiased Pair-Wise Discovery of SOCS1 and Regnase-1 As the Top CRISPR/Cas9 Dual-Edit Combination Enhancing in Vivo TIL Potency Against Solid Tumors

Karrie Wong,Christopher Wrocklage,Sharon Lin,Isabelle Le Mercier,Caroline Bullock,Louise Cadzow,Anja F. Hohmann, Stephen H. Shenker,Katri Sofjan,Leila J. Williams,Gregory V. Kryukov,Conor Calnan,Frank Stegmeier,Micah J. Benson,Michael R. Schlabach

Journal for immunotherapy of cancer（2021）

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