基本信息
views: 0
Career Trajectory
Bio
Research interests
Autoimmune diseases affect over 5 per cent of the population and are amongst the leading causes of mortality in young and middle aged women. Despite this, the causes of autoimmune disease remain poorly defined and there are no cures. Recent advances in sequencing technologies and bioinformatics now make it possible to identify rare/novel germline gene variants that may cause disease using whole exome/genome sequencing (WES/WGS). At the Centre for Personalised Immunology we are using these technologies to identify the mutations that may be causing disease in individual patients with the aim of tailoring therapy. We have recently sequenced a number of autoimmune patients. The project will involve identifying potential disease-causing genetic variants and then performing PCR and Sanger sequencing to confirm SNV genotypes and disease segregation among other family members. Confirmed candidate SNVs would then be cloned and biochemical assays performed to test protein stability and function. Cellular and or mouse studies may also be performed to determine contribution of variant to SLE disease pathogenesis.
Autoimmune diseases affect over 5 per cent of the population and are amongst the leading causes of mortality in young and middle aged women. Despite this, the causes of autoimmune disease remain poorly defined and there are no cures. Recent advances in sequencing technologies and bioinformatics now make it possible to identify rare/novel germline gene variants that may cause disease using whole exome/genome sequencing (WES/WGS). At the Centre for Personalised Immunology we are using these technologies to identify the mutations that may be causing disease in individual patients with the aim of tailoring therapy. We have recently sequenced a number of autoimmune patients. The project will involve identifying potential disease-causing genetic variants and then performing PCR and Sanger sequencing to confirm SNV genotypes and disease segregation among other family members. Confirmed candidate SNVs would then be cloned and biochemical assays performed to test protein stability and function. Cellular and or mouse studies may also be performed to determine contribution of variant to SLE disease pathogenesis.
Research Interests
Papers共 30 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Xin Gao,Qian Shen,Jonathan A. Roco, Becan Dalton,Katie Frith,C. Mee Ling Munier, Fiona D. Ballard, Ke Wang,Hannah G. Kelly,Maxim Nekrasov,Jin-Shu He, Rebecca Jaeger, Patricia Carreira,Julia I. Ellyard,Lynette Beattie,Anselm Enders,Matthew C. Cook,John J. Zaunders,Ian A. Cockburn
SCIENCE IMMUNOLOGYno. 93 (2024)
Yaoyuan Zhang,Rhiannon Morris,Grant J. Brown,Ayla May D. Lorenzo,Xiangpeng Meng,Nadia J. Kershaw,Pamudika Kiridena,Gaetan Burgio, Simon Gross,Jean Y. Cappello,Qian Shen,Hao Wang,Cynthia Turnbull,Tom Lea-Henry,Maurice Stanley,Zhijia Yu, Fiona D. Ballard,Aaron Chuah,James C. Lee,Ann-Maree Hatch,Anselm Enders,Seth L. Masters, Alexander P. Headley,Peter Trnka,Dominic Mallon,Jeffery T. Fletcher,Giles D. Walters,Mario Sestan,Marija Jelusic,Matthew C. Cook,Vicki Athanasopoulos,David A. Fulcher,Jeffrey J. Babon,Carola G. Vinuesa,Julia I. Ellyard
JOURNAL OF EXPERIMENTAL MEDICINEno. 4 (2024)
Arwaf S. Alharbi,Sunil Sapkota,Zhikuan Zhang,Ruitao Jin,W. Samantha N. Jayasekara, Erandi Rupasinghe,Mary Speir,Lorna Wilkinson-White,Roland Gamsjaeger,Liza Cubeddu,Julia I. Ellyard,Daniel S. Wenholz, Alexandra L. McAllan,Refaya Rezwan,Le Ying, Hani Hosseini Far,Josiah Bones,Sitong He,Dingyi Yu,Kim A. Lennox,Paul J. Hertzog,Carola G. Vinuesa,Mark A. Behlke,Umeharu Ohto,Olivier F. Laczka,Ben Corry,Toshiyuki Shimizu,Michael P. Gantier
biorxiv(2024)
Tomalika R. Ullah,Matt D. Johansen,Katherine R. Balka,Rebecca L. Ambrose,Linden J. Gearing, James Roest,Julian P. Vivian,Sunil Sapkota,W. Samantha N. Jayasekara,Daniel S. Wenholz,Vina R. Aldilla,Jun Zeng,Stefan Miemczyk,Duc H. Nguyen,Nicole G. Hansbro,Rajan Venkatraman,Jung Hee Kang,Ee Shan Pang,Belinda J. Thomas,Arwaf S. Alharbi,Refaya Rezwan,Meredith O’Keeffe,William A. Donald,Julia I. Ellyard,Wilson Wong,Naresh Kumar,Benjamin T. Kile,Carola G. Vinuesa,Graham E. Kelly,Olivier F. Laczka,Philip M. Hansbro,Dominic De Nardo,Michael P. Gantier
Cynthia Turnbull,Josiah Bones,Maurice Stanley, Arti Medhavy,Hao Wang,Ayla May D. Lorenzo,Jean Cappello,Somasundhari Shanmuganandam,Abhimanu Pandey,Sandali Seneviratne,Grant J. Brown,Xiangpeng Meng,David Fulcher,Gaetan Burgio,Si Ming Man,Carmen de Lucas Collantes,Mercedes Gasior,Eduardo Lopez Granados,Pilar Martin,Simon H. Jiang,Matthew C. Cook,Julia I. Ellyard,Vicki Athanasopoulos,Ben Corry,Pablo F. Canete,Carola G. Vinuesa
Rheumatology & autoimmunityno. 1 (2022): 15-25
Grant J. Brown,Pablo F. Canete,Hao Wang, Arti Medhavy,Josiah Bones,Jonathan A. Roco,Yuke He,Yuting Qin,Jean Cappello,Julia I. Ellyard,Katharine Bassett,Qian Shen,Gaetan Burgio,Yaoyuan Zhang,Cynthia Turnbull,Xiangpeng Meng, Phil Wu,Eun Cho,Lisa A. Miosge,T. Daniel Andrews,Matt A. Field,Denis Tvorogov,Angel F. Lopez,Jeffrey J. Babon,Cristina Aparicio Lopez,Africa Gonzalez-Murillo,Daniel Clemente Garulo,Virginia Pascual,Tess Levy,Eric J. Mallack,Daniel G. Calame,Timothy Lotze,James R. Lupski,Huihua Ding,Tomalika R. Ullah,Giles D. Walters,Mark E. Koina,Matthew C. Cook,Nan Shen,Carmen de Lucas Collantes,Ben Corry,Michael P. Gantier,Vicki Athanasopoulos,Carola G. Vinuesa
Michael P. Gantier,Tomalika R. Ullah,Matt D. Johansen,Katherine R. Balka,Rebecca L. Ambrose,Linden J. Gearing,Daniel S. Wenholz,Jun Zeng,Stefan Miemczyk,Duc Nguyen,Rajan Venkatraman,Matthew L. Dennis,Arwaf Alharbi,Julia I. Ellyard,Wilson Wong,Benjamin T. Kile,Carola G. Vinuesa,Graham Kelly,Philip M. Hansbro,Olivier Laczka,Dominic De Nardo,Nicole G. Hansbro,Naresh Kumar
Research Square (Research Square) (2022)
Load More
Author Statistics
#Papers: 30
#Citation: 2062
H-Index: 15
G-Index: 19
Sociability: 6
Diversity: 2
Activity: 59
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn