Research interests
The Bruestle Group - Inflammatory T Cell Responses, is focusing on different T helper cell subsets and how they modulate immunity in diverse autoimmune mouse models. A special interest of this group is the CD4 subset of inflammatory Th17 cells. Using genetically modified mouse strains they analyse the differentiation and effector function of these cells in vitro as well as in in vivo models. Their research relates to human autoimmune diseases such as multiple sclerosis, psoriasis or inflammatory bowel disease, all of which have been associated to deregulated Th17 cell responses.