He is actively involved in the design and execution of many acute and chronic heart failure clinical trials, serving on endpoint, data safety monitoring, and steering committees for numerous international studies investigating a variety of new therapies, including tezosentan (RITZ program, VERITAS), levosimendan (REVIVE 1&2), nesiritide (ASCEND-HF), serelaxin (Pre-RELAX-AHF, RELAX-AHF, RELAX-AHF-2, RELAX-ASIA, RELAX-Repeat), rolofylline (PROTECT), omecamtiv mecarbil (CY1111, CY1121, ATOMIC-AHF, COSMIC-HF, GALACTIC-HF, METEORIC-HF), TRV027 (BLAST-AHF), warfarin/ clopidogrel/ aspirin (WATCH, WARCEF), nitroxyl donor (STANDUP-AHF), fineranone (FIGARRO, FIDELIO), LCZ696 (sacubitril/ valsartan; PARADIGM-HF), and empagliflozin (EMPEROR-Preserved, EMPEROR-Reduced, DINAMO), as well as stem cell therapies (CHART-1) and diagnostic modalities, such as CardioMEMS device (CHAMPION, CardioMEMS Post-approval Study), left atrial pressure sensor (LAPTOP-HF) and other devices (ADAPT-Response).