He is currently a Professor of Biomedical Engineering in the Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece, where he is also the Director of the Unit of Medical Technology and Intelligent Information Systems, and is also an Affiliated Member of Foundation for Research and Technology Hellas, Institute of Molecular Biology and Biotechnology, Dept. of Biomedical Research. He was a Visiting Researcher at the RWTH, Aachen, Germany, and the Massachusetts Institute of Technology, Boston. He has coordinated and participated in more than 200 R&D funded projects. He is the author or coauthor of more than 220 papers in scientific journals, 400 papers in peer-reviewed conference proceedings, and more than 45 chapters in books. He is also the editor or coeditor of 25 books. His work has received more than 8500 citations (h-index = 46). He is a senior member of IEEE, member of IEEE Technical Committee of information Technology in Healthcare and the Editor in Chief of IEEE Journal of Biomedical and Health Informatics and Associate Editor for Computers in Biology and Medicine. His research interests include multiscale modeling of human tissues and organs, intelligent wearable/implantable devices for automated diagnosis, processing of big medical data, sensor informatics, image informatics, and bioinformatics.