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Physical Drivers And Dominant Oceanographic Processes On The Uruguayan Margin (Southwestern Atlantic): A Review And A Conceptual Model

Journal of marine science and engineering(2021)SCI 3区SCI 4区

Univ Republica | Univ Republ | Univ Sao Paulo | Minist Ganaderia Agr & Pesca

Cited 4|Views21
Abstract
The Uruguayan continental margin (UCM), located in the Southwestern Atlantic margin's subtropical region, is positioned in a critical transitional region regarding the global ocean circulation (Rio de la Plata (RdlP) outflow and Brazil-Malvinas Confluence), as also reflected in seafloor features (northernmost distribution of a large depositional contourite system and RdlP paleovalley). This complex oceanographic scenario occurring in a relatively small area highlights the advantage of considering the UCM as a natural laboratory for oceanographic research. The present work provides the first conceptual "control" model of the physical drivers (i.e., climate, geomorphology) and main oceanographic processes (i.e., hydrodynamics, sediment, and carbon dynamics) occurring along the UCM, reviewing and synthesizing available relevant information based on a functional integrated approach. Despite the conspicuous knowledge gaps on critical processes, a general picture of the system's functioning is emerging for this complex biophysical setting. This includes conceptualizations of the actual controls, main processes, feedbacks, and interactions responsible for system dynamics. The structure adopted for developing our conceptual models allows permanent improvement by empirical testing of the working hypothesis and incorporating new information as scientific knowledge advances. These models can be used as a baseline for developing quantitative models and, as representations of relatively "pristine" conditions, for stressors models by identifying sources of stress and ecological responses of key system attributes under a transboundary approach.
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Uruguayan margin, Southwestern Atlantic, conceptual models
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要点】:通过在全局时钟缺失的小鼠的视交叉上核(SCN)中恢复分子时钟功能,可以启动昼夜节律活动-休息周期,稳定睡眠-觉醒周期并逆转记忆缺陷。

方法】:使用病毒介导的遗传补充,表达Cryptochrome1(Cry1)在全局时钟缺失、节律失调的雄性Cry1/Cry2-null小鼠的视交叉上核中建立昼夜节律分子能力。

实验】:在自由运行条件下,表达EGFP的对照组(SCNCon)表现出无节律的休息/活动行为,而Cry1补充的小鼠(SCNCry1)表现出与Cry1,2-competent野生型(WTs)相似的协调昼夜行为。通过脑电图(EEG)/肌电图(EMG)评估,SCNCon小鼠的睡眠-觉醒状态缺乏昼夜组织,而SCNCry1小鼠的睡眠-觉醒状态与WTs相匹配,具有巩固的警觉状态(清醒、快速眼动睡眠(REMS)和非快速眼动睡眠(NREMS))以及NREMS δ功率和REMS在总睡眠(TS)中的节律。SCNCon小鼠的清醒状态比WTs更碎片化,SCNCry1小鼠则逆转了这种破裂。睡眠剥夺(SD)后,所有小鼠的NREMS δ功率都有家态性增加,尽管SCNCon小鼠在恢复的静止(光)阶段NREMS减少,而SCNCry1小鼠的家态性响应动态与WTs相似。此外,SCNCon小鼠表现出睡眠依赖性记忆差,但SCNCry1小鼠纠正了这一点。使用的数据集名称未提及。