基本信息
views: 7
Career Trajectory
Bio
Recognition
2016: Washington University School of Medicine Alumni Achievement Award
2009: The American Society for Clinical Investigation Elected Member
2007: American Society for Bone and Mineral Research (ASBMR) Career Enhancement Award
2004: Harold Frost Young Investigator Award
2001: American Society for Bone and Mineral Research (ASBMR) Young Investigator Award
1993: Spencer T. and Ann Olin Award for Excellence in Graduate Research, Washington University
Research Interests
My lab studies mechanisms of pathological bone loss. Most work has focused on the study of osteoclasts, the cells that resorb/remove bone to allow normal bone turnover. These cells are hematopoietic-derived cells of the monocyte lineage that differentiate in the bone microenvironment under the influence of the cytokine RANKL. OCs attach to the bone surface via integrins and form an extracellular compartment, the resorption lacuna, into which they secrete acid and proteases to degrade the organic and mineral components of bone. Activity of these cells is critical for bone homeostasis, but their abnormal activation is responsible for pathological bone loss in many settings, including osteolytic tumor metastases and infection. We use a combination of disease models, genetic mouse models, and in vitro cultures, providing a broad range of potential research projects as well as diverse technical approaches. Our current active projects include investigation of the role of the inflammasome in S. aureus-mediated osteomyelitis, and tumor-bone interactions in HTLV-1/acute T cell leukemia.
2016: Washington University School of Medicine Alumni Achievement Award
2009: The American Society for Clinical Investigation Elected Member
2007: American Society for Bone and Mineral Research (ASBMR) Career Enhancement Award
2004: Harold Frost Young Investigator Award
2001: American Society for Bone and Mineral Research (ASBMR) Young Investigator Award
1993: Spencer T. and Ann Olin Award for Excellence in Graduate Research, Washington University
Research Interests
My lab studies mechanisms of pathological bone loss. Most work has focused on the study of osteoclasts, the cells that resorb/remove bone to allow normal bone turnover. These cells are hematopoietic-derived cells of the monocyte lineage that differentiate in the bone microenvironment under the influence of the cytokine RANKL. OCs attach to the bone surface via integrins and form an extracellular compartment, the resorption lacuna, into which they secrete acid and proteases to degrade the organic and mineral components of bone. Activity of these cells is critical for bone homeostasis, but their abnormal activation is responsible for pathological bone loss in many settings, including osteolytic tumor metastases and infection. We use a combination of disease models, genetic mouse models, and in vitro cultures, providing a broad range of potential research projects as well as diverse technical approaches. Our current active projects include investigation of the role of the inflammasome in S. aureus-mediated osteomyelitis, and tumor-bone interactions in HTLV-1/acute T cell leukemia.
Research Interests
Papers共 221 篇Author StatisticsCo-AuthorSimilar Experts
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Jiayu Ye,John M. Baer,Douglas V. Faget,Vasilios A. Morikis,Qihao Ren, Anupama Melam,Ana Paula Delgado,Xianmin Luo,Satarupa Mullick Bagchi,Jad I. Belle, Edward Campos, Michael Friedman,Deborah J. Veis,Erik S. Knudsen,Agnieszka K. Witkiewicz,Scott Powers,Gregory D. Longmore,David G. DeNardo,Sheila A. Stewart
Xinming Su,Takayuki Kobayashi,Jingyu Xiang,Yalin Xu,Ayesha N. Shajahan-Haq,Mahta Mardani, Suleyman Noordeen, Kaylee O'Donnell,Kristin A. Kwakwa,Francesca Fontana,Deborah J. Veis,Gregory M. Lanza,Katherine N. Weilbaecher
Journal of Bone Oncology (2024): 100538
Chia-Kuei Mo,Jingxian Liu,Siqi Chen,Erik Storrs, Andre Luiz N. Targino da Costa,Andrew Houston,Michael C. Wendl,Reyka G. Jayasinghe,Michael D. Iglesia,Cong Ma,John M. Herndon,Austin N. Southard-Smith,Xinhao Liu,Jacqueline Mudd,Alla Karpova,Andrew Shinkle,S. Peter Goedegebuure, Abdurrahman Taha Mousa Ali Abdelzaher, Peng Bo, Lauren Fulghum, Samantha Livingston,Metin Balaban,Angela Hill,Joseph E. Ippolito,Vesteinn Thorsson,Jason M. Held,Ian S. Hagemann,Eric H. Kim,Peter O. Bayguinov,Albert H. Kim,Mary M. Mullen,Kooresh I. Shoghi,Tao Ju, Melissa A. Reimers,Cody Weimholt, Liang- Kang,Sidharth V. Puram,Deborah J. Veis, Russell Pachynski,Katherine C. Fuh,Milan G. Chheda,William E. Gillanders,Ryan C. Fields,Benjamin J. Raphael, Feng Chen,Li Ding
NATUREno. 8036 (2024)
Hannah K Dorando,Evan C Mutic, Kelly L Tomaszewski,Ling Tian, Mellisa K Stefanov,Chaz C Quinn,Deborah J Veis,Juliane Bubeck Wardenburg,Amy C Musiek,Neha Mehta-Shah,Jacqueline E Payton
bioRxiv the preprint server for biology (2024)
Nitin Kumar Pokhrel,Amanda R. Panfil, Haniya Habib, Shamreethaa Seeniraj,Ancy Joseph,Daniel Rauch,Linda Cox,Robert Sprung,Petra Erdmann Gilmore,Qiang Zhang,Robert Reid Townsend,Lianbo Yu,Ayse Selen Yilmaz,Rajeev Aurora, William Park,Lee Ratner,Katherine N. Weilbaecher,Deborah J. Veis
JOURNAL OF EXTRACELLULAR VESICLESno. 10 (2024)
Michael D Iglesia,Reyka G Jayasinghe,Siqi Chen,Nadezhda V Terekhanova,John M Herndon,Erik Storrs,Alla Karpova,Daniel Cui Zhou,Nataly Naser Al Deen,Andrew T Shinkle, Rita Jui-Hsien Lu,Wagma Caravan,Andrew Houston,Yanyan Zhao,Kazuhito Sato,Preet Lal,Cherease Street,Fernanda Martins Rodrigues,Austin N Southard-Smith, André Luiz N Targino da Costa,Houxiang Zhu,Chia-Kuei Mo, Lisa Crowson,Robert S Fulton,Matthew A Wyczalkowski,Catrina C Fronick,Lucinda A Fulton,Hua Sun,Sherri R Davies,Elizabeth L Appelbaum,Sara E Chasnoff, Madelyn Carmody, Candace Brooks,Ruiyang Liu,Michael C Wendl,Clara Oh,Diane Bender,Carlos Cruchaga,Oscar Harari,Andrea Bredemeyer,Kory Lavine,Ron Bose,Julie Margenthaler,Jason M Held,Samuel Achilefu,Foluso Ademuyiwa,Rebecca Aft,Cynthia Ma,Graham A Colditz,Tao Ju,Stephen T Oh,James Fitzpatrick,E Shelley Hwang,Kooresh I Shoghi,Milan G Chheda,Deborah J Veis,Feng Chen,Ryan C Fields,William E Gillanders,Li Ding
Nature cancerno. 11 (2024): 1713-1736
bioRxiv the preprint server for biology (2024)
Gregory C. Fox,Xinming Su,Jennifer L. Davis,Yalin Xu,Kristin A. Kwakwa,Michael H. Ross,Francesca Fontana,Jingyu Xiang,Alison K. Esser,Elizabeth Cordell,Kristen Pagliai,Ha X. Dang,Jothilingam Sivapackiam,Sheila A. Stewart,Christopher A. Maher,Suzanne J. Bakewell, James A.J. Fitzpatrick,Vijay Sharma, Samuel Achilefu,Deborah J. Veis,Gregory M. Lanza,Katherine N. Weilbaecher
openalex(2023)
Nitin Pokhrel,Amanda Panfil, Haniya Habib, Sham Seeniraj,Ancy Joseph,Daniel Rauch,Robert Sprung,Petra Gilmore,Qiang Zhang,Reid Townsend,Yu Lianbo, Ayse Selen Yimaz,Rajeev Aurora, William Park,Lee Ratner,Katherine Weilbaecher,Deborah Veis
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 25-25
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Author Statistics
#Papers: 222
#Citation: 8706
H-Index: 49
G-Index: 91
Sociability: 7
Diversity: 3
Activity: 95
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