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论文共 72 篇作者统计合作学者相似作者

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Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients

Kyunghee Yang,Ronald Kong,Robert Spiegel,John D. Baird,Kylie O'Keefe,Brett A. Howell,Paul B. Watkins

CLINICAL PHARMACOLOGY & THERAPEUTICSno. 3 (2024): 525-534

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Quantitative Systems Toxicology (QST) Modeling Using a New Virtual Population in BIOLOGXsym Offers Mechanistic Insights into Bile Acid-Mediated Biologics-Induced Liver Injury (BILI) Upon Cimaglermin Alfa (GGF2) Administration

Brett A. Howell,James J. Beaudoin,Lawrence A. Vernetti,D. Lansing Taylor,Albert H. Gough, Lara Clemens,Christina Battista,Scott Q. Siler,Lisl K. M. Shoda,Kyunghee Yang

INTERNATIONAL JOURNAL OF TOXICOLOGYno. 1 (2024): 105-106

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Prediction of the Liver Safety Profile of a First-in-class Myeloperoxidase Inhibitor Using Quantitative Systems Toxicology Modeling

Jeffrey L. Woodhead, Yeshi Gebremichael, Joyce Macwan, Irfan A. Qureshi,Richard Bertz,Victoria Wirtz,Brett A. Howell

XENOBIOTICAno. 7 (2024): 401-410

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Investigating Bile Acid-Mediated Cholestatic Drug-Induced Liver Injury Using a Mechanistic Model of Multidrug Resistance Protein 3 (MDR3) Inhibition

James J. Beaudoin,Kyunghee Yang,Jeffry Adiwidjaja,Guncha Taneja,Paul B. Watkins,Scott Q. Siler,Brett A. Howell,Jeffrey L. Woodhead

Carolina Digital Repository (University of North Carolina at Chapel Hill)（2023）

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

James J. Beaudoin, Lara Clemens,Mark T. Miedel,Albert Gough, Fatima Zaidi, Priya Ramamoorthy,Kari E. Wong, Rangaprasad Sarangarajan,Christina Battista,Lisl K. M. Shoda,Scott Q. Siler,D. Lansing Taylor,Brett A. Howell,Lawrence A. Vernetti,Kyunghee Yang

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 11 (2023)

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Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology

Vinal V. V. Lakhani,Grant Generaux,Brett A. A. Howell,Diane M. M. Longo,Paul B. B. Watkins

Clinical Pharmacology &amp Therapeuticsno. 5 (2023): 1006-1014

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Mechanistic Investigation of Liver Injury Induced by BMS-932481, an Experimental ɣ-Secretase Modulator

Xiaoliang Zhuo,Brett A Howell,Hong Shen,Jeffrey L Woodhead,Kathy Mosure,Yueping Zhang,Renato J Scialis,Ramaswamy Iyer,Yongnian Sun,Kenneth M Boy,Kimberly A Lentz,Rex Denton,Matthew G Soars,Benjamin M Johnson,W Griffith Humphreys

Toxicological sciences : an official journal of the Society of Toxicologyno. 2 (2023): 235-245

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Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Jeffrey L. Woodhead,Scott Q. Siler,Brett A. Howell,Paul B. Watkins,Charles Conway

TOXICOLOGICAL SCIENCES（2022）

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Mechanistic Modeling of Kidney-Injury Molecule 1 (KIM-1) As a Biomarker for Cisplatin-Induced AKI

Nader Hamzavi,Yeshitila Gebremichael,Jeffrey L. Woodhead, Sergey Ermakov,Brett A. Howell

Journal of the American Society of Nephrologyno. 10S (2021): 170-170

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ADVANCING CALCITONIN GENE-RELATED PEPTIDE RECEPTOR (CGRP) ANTAGONISTS USING QUANTITATIVE SYSTEMS TOXICOLOGY MODELING TO CHARACTERIZE NEXT-IN-CLASS COMPOUNDS COMPARED TO THE HEPATOTOXIC FIRST IN CLASS TELCAGEPANT

Scott Q. Siler,Jeffrey Woodhead,Brett Howell,Charles Conway,Paul B. Watkins

HEPATOLOGY（2021）

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