Albert Gough

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Comparison of Wild-Type and High-risk PNPLA3 Variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacin,Dillon C. Gavlock,Richard De Biasio, Gregory La Rocca,Celeste Reese,Rodrigo M. Florentino,Lanuza A. P. Faccioli,Jacquelyn A. Brown,Lawrence A. Vernetti,Mark Schurdak,Andrew M. Stern,Albert Gough,Jaideep Behari,Alejandro Soto-Gutierrez,D. Lansing Taylor,Mark T. Miedel

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY（2024）

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Quantitative Systems Toxicology (QST) Modeling Using a New Virtual Population in BIOLOGXsym Offers Mechanistic Insights into Bile Acid-Mediated Biologics-Induced Liver Injury (BILI) Upon Cimaglermin Alfa (GGF2) Administration

Brett A. Howell,James J. Beaudoin,Lawrence A. Vernetti,D. Lansing Taylor,Albert H. Gough, Lara Clemens,Christina Battista,Scott Q. Siler,Lisl K. M. Shoda,Kyunghee Yang

INTERNATIONAL JOURNAL OF TOXICOLOGYno. 1 (2024): 105-106

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A Metabolic-Dysfunction Associated Steatotic Liver Acinus Biomimetic Induces Pancreatic Islet Dysfunction in a Coupled Microphysiology System

Julio Aleman,K. Ravikumar,Connor Wiegand,Mark E. Schurdak,Lawrence Vernetti,Dillon Gavlock,Celeste Reese,Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita,Albert Gough,Alejandro Soto-Gutierrez,Jaideep Behari,Vijay K. Yechoor,Mark T. Miedel,Andrew M. Stern,Ipsita Banerjee,D. Lansing Taylor

COMMUNICATIONS BIOLOGYno. 1 (2024)

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Modeling Mechanisms Underlying Differential Inflammatory Responses to COVID-19 in Type 2 Diabetes Using a Patient-Derived Microphysiological Organ-on-a-chip System

Vinny Negi,Dillon Gavlock,Mark T. Miedel,Jeong Kyung Lee,Tongying Shun,Albert Gough,Lawrence Vernetti,Andrew M. Stern,D. Lansing Taylor,Vijay K. Yechoor

Lab on a Chip (2023)

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

James J. Beaudoin, Lara Clemens,Mark T. Miedel,Albert Gough, Fatima Zaidi, Priya Ramamoorthy,Kari E. Wong, Rangaprasad Sarangarajan,Christina Battista,Lisl K. M. Shoda,Scott Q. Siler,D. Lansing Taylor,Brett A. Howell,Lawrence A. Vernetti,Kyunghee Yang

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 11 (2023)

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Clinical concordance of in vitro, animal and human toxicology studies in the setting of acute kidney injury

J.C. Maggiore, M. Castiglione, A. Shah, E. Streeter,A. Gough, M. Schurdak, L. Taylor, N.A.H. Hukriede

Journal of Critical Care (2023): 154202-154202

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831-P: Tocilizumab is Effective in Reducing Inflammation in T2D–COVID-Organ-on-a-Chip Model

Vinny Negi,Dillon Gavlock,Jeongkyung Lee,Tongying Shun,Albert Gough,Mark T. Miedel,D. Lansing L. Taylor,Vijay Yechoor

Diabetes（2022）

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ヒトマイクロ流体4細胞肝臓acinusマイクロ生理学システム(LAMPS)の再現性とロバスト性の解析【JST・京大機械翻訳】

Sakolish Courtney,E Reese Celeste,Luo Yu-Syuan,Valdiviezo Alan,Eden Mark,G Albert,Taylor D. Lansing,A Chiu Weihsueh,A Vernetti Lawrence,Ivan Rusyn

Toxicology (2021)

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Human biomimetic liver microphysiology systems in drug development and precision medicine

Gough, Albert,Soto-Gutierrez, Alejandro,Vernetti, Lawrence, Ebrahimkhani, Mo R.,Stern, Andrew M.,Taylor, D. Lansing

Nature Reviews Gastroenterology & Hepatology（2021）

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