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Research synopsis
We are an interdisciplinary and interactive research group based in UCL LMCB and Department of Physics and Astronomy. We bring together ideas and tools from theoretical and computational physics and chemistry to develop fundamental understanding behind complex life processes.
Our research is centered around protein assembly in life and disease: how proteins create the macromolecular machinery of life, and how pathological protein aggregation involved in neurodegenerative disease occurs. We are particularly focused on cell reshaping and cutting by ESCRT filaments, protein assembly under chemical and mechanical gradients, and pathological amyloid aggregation. We develop minimal computer models, in a close collaboration with experimental colleagues, to explain and predict the molecular steps involved in these complex phenomena.
We are an interdisciplinary and interactive research group based in UCL LMCB and Department of Physics and Astronomy. We bring together ideas and tools from theoretical and computational physics and chemistry to develop fundamental understanding behind complex life processes.
Our research is centered around protein assembly in life and disease: how proteins create the macromolecular machinery of life, and how pathological protein aggregation involved in neurodegenerative disease occurs. We are particularly focused on cell reshaping and cutting by ESCRT filaments, protein assembly under chemical and mechanical gradients, and pathological amyloid aggregation. We develop minimal computer models, in a close collaboration with experimental colleagues, to explain and predict the molecular steps involved in these complex phenomena.
研究兴趣
论文共 83 篇作者统计合作学者相似作者
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BIOPHYSICAL JOURNALno. 3 (2024): 307-316
Proceedings of the National Academy of Sciences of the United States of Americano. 7 (2024): e2220075121-e2220075121
Fredrik Hurtig,Thomas C. Q. Burgers, Alice Cezanne,Xiuyun Jiang,Frank N. Mol,Jovan Traparić, Andre Arashiro Pulschen,Tim Nierhaus,Gabriel Tarrason-Risa,Lena Harker-Kirschneck, Jan Löwe,Anđela Šarić,
Science Advancesno. 11 (2023)
Nature Reviews Physicsno. 7 (2023): 379-397
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NATUREno. 7990 (2023): E3-E3
Nature Physicsno. 11 (2023): 1680-1688
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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