Research synopsis
We are an interdisciplinary and interactive research group based in UCL LMCB and Department of Physics and Astronomy. We bring together ideas and tools from theoretical and computational physics and chemistry to develop fundamental understanding behind complex life processes.
Our research is centered around protein assembly in life and disease: how proteins create the macromolecular machinery of life, and how pathological protein aggregation involved in neurodegenerative disease occurs. We are particularly focused on cell reshaping and cutting by ESCRT filaments, protein assembly under chemical and mechanical gradients, and pathological amyloid aggregation. We develop minimal computer models, in a close collaboration with experimental colleagues, to explain and predict the molecular steps involved in these complex phenomena.