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A number of important anticancer agents intercalate into DNA, and the energetics of this interaction contributes to their cytotoxicity. The high affinity of intercalants results in the persistence of drug molecules in DNA giving rise to toxic effects (such as topoisomerase II interactions) which may lead to cell cycle arrest and DNA degradation. As part of a program designed to more fully understand the mechanism of cytotoxicity of chemotypes related to the anthracene-9,10-dione, mitoxantrone (1), we have synthesized bioisosteric analogues. The rationale for the study of these compounds is based on their higher ability to intercalate into DNA (relative to the carbocyclic model) which should decrease their dissociation rate from the complex, and therefore exhibit higher antitumor activity. We have shown that the position of the nitrogen atom in the heterocycle dramatically changes the antitumor response. The in vitro and in vivo data showed the 2-aza compound 2 was curative against L1210 murine leukemia whereas the 1-azaanthracene-9,10-dione was devoid of biological activity.
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#Papers: 171
#Citation: 3685
H-Index: 31
G-Index: 55
Sociability: 5
Diversity: 3
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