The research program of Richard J. Caselli, M.D., focuses on cognitive aging and the changes that can be detected before the symptomatic onset of memory loss and related symptoms of Alzheimer's disease.

Dr. Caselli's personal focus is on the neuropsychological and related behavioral changes that can be detected. But through a close series of collaborations, he is also involved in brain imaging (FDG-PET, PIB-PET and MRI), neuropathology, genomics, and epigenetic factors that influence Alzheimer's disease risk and age of onset.