基本信息
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职业迁徙
个人简介
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. We study genes (e.g. globin) in detail and also study gene expression using genome wide analyses. We study all aspects of gene expression including the key cis-regulatory elements (enhancers, promoters and insulators), the transcription factors and co-factors that bind them, the epigenetic modifications of chromatin and DNA and the role of associated phenomena such as chromosome conformation and nuclear sub-compartmentalisation using imaging techniques. These studies are performed both in cell systems and in model organisms as well as in human patients with various inherited and acquired genetic and epigenetic abnormalities. The translational goal of this work is to develop new ways to modify gene expression during blood formation with the aim of manipulating gene expression and ameliorating the clinical phenotypes of patients with a variety of blood disorders.
研究兴趣
论文共 501 篇作者统计合作学者相似作者
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引用量
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期刊级别
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合作机构
Scienceno. 6704 (2024)
BLOODno. 8 (2024): 822-833
Cornelis L Harteveld, Ahlem Achour, Nik Fatma Fairuz Mohd Hasan,Jelmer Legebeke,Sandra J G Arkesteijn, Jeanet Ter Huurne, Maaike Verschuren, Sharda Bhagwandien-Bisoen, Rianne Schaap, Linda Vijfhuizen,Hakima El Idrissi,Christian Babbs,Douglas R Higgs, Tamara T Koopmann, Christina Vrettou,Joanne Traeger-Synodinos,Frank Baas, International Hemoglobinopathy Research Network (INHERENT)
International journal of molecular sciencesno. 16 (2024)
Felice H. Tsang,Rosa J. Stolper,Muhammad Hanifi, Lucy J. Cornell,Helena S. Francis,Benjamin Davies,Douglas R. Higgs,Mira T. Kassouf
Nucleic acids researchno. 17 (2024): 10180-10193
Experimental Hematology (2024): 104306
Bloodno. 8 (2024): 822-833
Guanjue Xiang,Xi He,Belinda M Giardine, Kathryn J Isaac,Dylan J Taylor,Rajiv C McCoy,Camden Jansen,Cheryl A Keller,Alexander Q Wixom,April Cockburn,Amber Miller,Qian Qi,Yanghua He,Yichao Li,Jens Lichtenberg,Elisabeth F Heuston,Stacie M Anderson,Jing Luan,Marit W Vermunt,Feng Yue,Michael E G Sauria,Michael C Schatz,James Taylor, Berthold Göttgens,Jim R Hughes,Douglas R Higgs,Mitchell J Weiss, Yong Cheng,Gerd A Blobel,David M Bodine,Yu Zhang,Qunhua Li,Shaun Mahony,Ross C Hardison
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv : the preprint server for biology (2023)
BioEssays news and reviews in molecular, cellular and developmental biologyno. 10 (2023): e2300047-e2300047
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作者统计
#Papers: 501
#Citation: 29678
H-Index: 93
G-Index: 157
Sociability: 8
Diversity: 0
Activity: 2
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