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The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs. This system to turn genes off or on, modulating their levels of activity in different cell types is central to maintaining the complex biological system that is a multicellular organism.
What has become clear from large-scale genetic studies of human predisposition to common disease is that it is the control of the use of genes, rather than the genes themselves, that is frequently damaged. It is now known that functional elements other that genes exist in our DNA and these elements act as molecular switches which interact with the genes and control their use, however the mechanisms involved are not well understood. The Hughes group integrates both bench technologies and computational approaches to try and understand how these regulatory switches or enhancer elements work and how variations in their activity in our genomes leads to increased risk of developing common diseases, such as anemia, cancer, diabetes and autoimmune diseases.
What has become clear from large-scale genetic studies of human predisposition to common disease is that it is the control of the use of genes, rather than the genes themselves, that is frequently damaged. It is now known that functional elements other that genes exist in our DNA and these elements act as molecular switches which interact with the genes and control their use, however the mechanisms involved are not well understood. The Hughes group integrates both bench technologies and computational approaches to try and understand how these regulatory switches or enhancer elements work and how variations in their activity in our genomes leads to increased risk of developing common diseases, such as anemia, cancer, diabetes and autoimmune diseases.
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论文共 159 篇作者统计合作学者相似作者
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Sunniyat Rahman, Gianna Bloye,Nadine Farah,Jonas Demeulemeester,Joana R. Costa, David O'Connor,Rachael Pocock, Adam Turna, Lingyi Wang,SooWah Lee,Adele K. Fielding,Juliette Roels,
biorxiv(2024)
Guanjue Xiang, Xi He,Belinda M. Giardine, Kathryn J. Isaac, Dylan J. Taylor,Rajiv C. McCoy, Camden Jansen,Cheryl A. Keller, Alexander Q. Wixom,April Cockburn, Amber Miller,Qian Qi,
biorxiv(2024)
Cell Stem Cellno. 5 (2023): 722-740.e11
Rosa J Stolper, Felice H Tsang, Emily Georgiades,Lars LP Hanssen,Damien J Downes,Caroline L Harrold,Jim R Hughes,Robert A Beagrie,Benjamin Davies,Mira Kassouf,Doug Higgs
biorxiv(2023)
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BLOOD (2023): 935
bioRxiv : the preprint server for biology (2023)
Emily Georgiades,Caroline L. Harrold,Nigel Roberts,Mira Kassouf,Simone G. Riva, Edward Sanders,Helena S. Francis,Joseph Blayney,A. Marieke Oudelaar,Thomas A. Milne,Douglas R. Higgs,Jim Hughes
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Xiaosai Yao,Jing Tan, Kevin Junliang Lim,Joanna Koh,Wen Fong Ooi,Zhimei Li,Dachuan Huang,Manjie Xing, Yang Sun Chan, James Zhengzhong Qu,Su Ting Tay, Giovani Wijaya,
crossref(2023)
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2023)
Alistair T. Pagnamenta,Carme Camps,Edoardo Giacopuzzi,John M. Taylor,Mona Hashim,Eduardo Calpena,Pamela J. Kaisaki, Akiko Hashimoto,Jing Yu, Edward Sanders,Ron Schwessinger,Jim R. Hughes,
GENOME MEDICINEno. 1 (2023): 1-25
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