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Cancer is characterized by major transcriptional and epigenetic changes not only in the cancer cells but also in other cell types that jointly constitute the tumor microenvironment (TME). The cancer phenotype is ultimately a result of dynamically changing interactions between various cell types. While much of the focus of research in oncogenesis, metastasis, drug resistance and relapse has been on protein-coding mutations, a growing body of literature clearly points to an alternate mechanism centered on transcription heterogeneity and cellular plasticity that sets the stage for oncogenesis. Broadly, cancers hijack several developmental and homeostatic processes for proliferation, immune evasion, and therapy resistance. Precise molecular links between cancer and the developmental/homeostatic processes is of great interest. Further complicating functional investigation of cancers is that the very notion of a gene’s or a cell’s function may be highly context-specific and the knowledge of context-specific functions is highly incomplete. The research in Hannenhalli lab is organized into three broad areas addressing the challenges posed above: (1) Transcriptional heterogeneity, cellular plasticity, and regulatory mechanisms underlying oncogenesis, metastasis, and therapy response, (2) Intrinsic and extrinsic context-specific functionality of genes and cells, and (3) Developmental and homeostatic origins of cancer.
Cancer is characterized by major transcriptional and epigenetic changes not only in the cancer cells but also in other cell types that jointly constitute the tumor microenvironment (TME). The cancer phenotype is ultimately a result of dynamically changing interactions between various cell types. While much of the focus of research in oncogenesis, metastasis, drug resistance and relapse has been on protein-coding mutations, a growing body of literature clearly points to an alternate mechanism centered on transcription heterogeneity and cellular plasticity that sets the stage for oncogenesis. Broadly, cancers hijack several developmental and homeostatic processes for proliferation, immune evasion, and therapy resistance. Precise molecular links between cancer and the developmental/homeostatic processes is of great interest. Further complicating functional investigation of cancers is that the very notion of a gene’s or a cell’s function may be highly context-specific and the knowledge of context-specific functions is highly incomplete. The research in Hannenhalli lab is organized into three broad areas addressing the challenges posed above: (1) Transcriptional heterogeneity, cellular plasticity, and regulatory mechanisms underlying oncogenesis, metastasis, and therapy response, (2) Intrinsic and extrinsic context-specific functionality of genes and cells, and (3) Developmental and homeostatic origins of cancer.
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论文共 247 篇作者统计合作学者相似作者
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Sumit Mukherjee,Arashdeep Singh, Hyunjeong Joo, Sumeet Patiyal, Hyungsoo Kim,Lipika R. Pal,Kun Wang,Chi-Ping Day, Ze’ev A. Ronai,Eytan Ruppin,Sridhar Hannenhalli
Cancer Researchno. 7_Supplement (2024)
Etan R. Aber,Cristina F. Contreras, Mohd Omar Sikder, Kathy P. Li, Greta E. Forbes,Vishaka Gopalan,Sridhar Hannenhalli,Rosandra N. Kaplan
Cancer Researchno. 7_Supplement (2024)
Cancer Researchno. 7_Supplement (2024)
Vishaka Gopalan,Chun Wai Wong,Chi-Ping Day,Eva Perez-Guijarro,Maxwell P. Lee, Yuhong Jiang,Howard H. Yang, Maira Alves-Constantino,Antonella Sassano,Cari Smith,Mark Simpson,Sung Chin,
Cancer Researchno. 7_Supplement (2024)
bioRxiv : the preprint server for biology (2023)
bioRxiv : the preprint server for biology (2023)
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Cancer Researchno. 8_Supplement (2023): LB285-LB285
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Science Advancesno. 7 (2023): eadd2911-eadd2911
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