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个人简介
My research is focused on developing and harnessing computational systems biology approaches for the genomic analysis and genome scale metabolic modeling (GSMM) of cancer. My lab collaborates with several experimental cancer labs, aiming to utilize computational approaches to jointly gain a network-level integrative view of the systems we study, and predict and test novel drug targets and biomarkers to treat cancer more selectively and effectively. My lab has developed the first GSMM models of metabolism of different human tissues, identified the first GSMM-based synthetic lethal drug target to treat renal cancer, has been the first to identify synthetic lethal networks in cancer in a genome-wide manner [3], and together with our experimental collaborators, has recently identified the essential role of aspartate in ASS1-deficient tumors
研究兴趣
论文共 603 篇作者统计合作学者相似作者
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Nature Machine Intelligenceno. 3 (2024): 307-314
Nishanth Ulhas Nair,Alejandro A Schäffer,E Michael Gertz,Kuoyuan Cheng,Johanna Zerbib,Avinash Das Sahu, Gil Leor, Eldad D Shulman,Kenneth D Aldape,Uri Ben-David,Eytan Ruppin
bioRxiv : the preprint server for biology (2024)
Eldad David Shulman,Danh-Tai Hoang,Rust Turakulov,Zied Abdullaev,Omkar Singh, Emma M. Campagnolo, Eric A. Stone,MacLean P. Nasrallah,Eytan Ruppin,Kenneth Aldape
Cancer Researchno. 6_Supplement (2024): 886-886
NATURE COMMUNICATIONSno. 1 (2023): 1-17
Livnat Jerby, Lior Wolf,Carsten Denkert, Gideon Y. Stein,Mika Hilvo,Matej Oresic,Tamar Geiger,Eytan Ruppin
crossref(2023)
Gal Dinstag, Eldad D. Shulman, Efrat Elis,Doreen S. Ben-Zvi,Omer Tirosh, Eden Maimon,Isaac Meilijson, Emmanuel Elalouf, Boris Temkin, Philipp Vitkovsky,Eyal Schiff,Danh-Tai Hoang,
Cancer Researchno. 7_Supplement (2023): 957-957
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Livnat Jerby, Lior Wolf,Carsten Denkert,Gideon Y. Stein,Mika Hilvo,Matej Oresic,Tamar Geiger,Eytan Ruppin
crossref(2023)
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