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Retinal growth, development and regeneration
In the vertebrate retina Müller glia have multiple roles - light guides, support cells and injury-induced stem cells. In the fish retina, when Müller glia function as stem cells, they completely replace dying cells and restore visual function. Following retinal injury, Müller glia re-enter the cell cycle and generate rapidly dividing progenitors that give rise to the regenerated neurons. When the neuronal death is extensive, this regenerative neurogenesis can replace all cell types, whereas, if death is limited to photoreceptors, only photoreceptors are regenerated. Understanding stem cell-based genesis and regeneration of neurons and photoreceptors is the focus of our work, and our goal is to identify the molecular mechanisms that guide stem cells in both the developing an injured retina to generate neurons and photoreceptors.
Retinal growth, development and regeneration
In the vertebrate retina Müller glia have multiple roles - light guides, support cells and injury-induced stem cells. In the fish retina, when Müller glia function as stem cells, they completely replace dying cells and restore visual function. Following retinal injury, Müller glia re-enter the cell cycle and generate rapidly dividing progenitors that give rise to the regenerated neurons. When the neuronal death is extensive, this regenerative neurogenesis can replace all cell types, whereas, if death is limited to photoreceptors, only photoreceptors are regenerated. Understanding stem cell-based genesis and regeneration of neurons and photoreceptors is the focus of our work, and our goal is to identify the molecular mechanisms that guide stem cells in both the developing an injured retina to generate neurons and photoreceptors.
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bioRxiv : the preprint server for biologyno. 1 (2023): 8477-8477
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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