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Calcium is the most common signal transduction element in virtually all cells ranging from bacteria to neurons. Recent studies have demonstrated the importance of transient receptor potential (TRP) channels in mediating calcium signals. The mammalian TRP channel superfamily consists of a diverse group of calcium permeable nonselective cation channels that may play a role in pain transduction, thermo-sensation, mechanotransduction, tumor suppression, vasodilatation, and neurodegenerative disorder. Twenty-eight mammalian TRP channel genes have been cloned since the first TRP channel protein was identified in Drosophila , yet their physiological functions are to be revealed.
We are interested in calcium signaling mechanisms and their potential roles under physiological and pathological conditions. We apply a multidisciplinary approach to study the potential functions of the calcium-permeable TRP channels. We use molecular biology and biochemistry approaches to identify channel proteins and the associated partners; we use patch-clamp to study channel functions and gating mechanisms; and we use in vivo transgenic animal models to investigate physiological or pathological functions of the TRP channels.
Our current research projects include:
TRP channels and calcium signaling mechanisms in cardiac fibrogenesis.
Gating mechanism and physiological functions of TRPM7 and TRPM6, the two channel-kinase proteins that exhibit both channel functions and protein kinase activities.
Gating mechanisms and potential roles of TRPM2
Calcium is the most common signal transduction element in virtually all cells ranging from bacteria to neurons. Recent studies have demonstrated the importance of transient receptor potential (TRP) channels in mediating calcium signals. The mammalian TRP channel superfamily consists of a diverse group of calcium permeable nonselective cation channels that may play a role in pain transduction, thermo-sensation, mechanotransduction, tumor suppression, vasodilatation, and neurodegenerative disorder. Twenty-eight mammalian TRP channel genes have been cloned since the first TRP channel protein was identified in Drosophila , yet their physiological functions are to be revealed.
We are interested in calcium signaling mechanisms and their potential roles under physiological and pathological conditions. We apply a multidisciplinary approach to study the potential functions of the calcium-permeable TRP channels. We use molecular biology and biochemistry approaches to identify channel proteins and the associated partners; we use patch-clamp to study channel functions and gating mechanisms; and we use in vivo transgenic animal models to investigate physiological or pathological functions of the TRP channels.
Our current research projects include:
TRP channels and calcium signaling mechanisms in cardiac fibrogenesis.
Gating mechanism and physiological functions of TRPM7 and TRPM6, the two channel-kinase proteins that exhibit both channel functions and protein kinase activities.
Gating mechanisms and potential roles of TRPM2
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Pengyu Zong,Jianlin Feng, Nicholas Legere,Yunfeng Li,Zhichao Yue, Cindy X. Li,Yasuo Mori,Barbara Miller,Bing Hao,Lixia Yue
Pengyu Zong,Jianlin Feng, Nicholas Legere,Yunfeng Li,Zhichao Yue, Cindy X. Li,Yasuo Mori,Barbara Miller,Bing Hao,Lixia Yue
Cell Reportsno. 2 (2024): 113722-113722
Neuroscience Bulletinpp.1-19, (2023)
Advances in neurobiology (2023): 171-202
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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British Journal of Pharmacologyno. S2 (2023): S145-S222
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