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Research in Dr. Abbott’s lab is focused on elucidating the molecular basis for ion channel and transporter physiology and pathophysiology. One of the main directions of the lab has been to define the roles of the KCNE and KCNQ gene families of potassium channel subunits, using a combination of techniques including mouse and human genetics, electrophysiology, pharmacology, transcriptomics, and state-of-the-art imaging modalities. This includes research stemming from our unexpected discovery that the neurotransmitter GABA and related molecules can bind directly to certain voltage-gated potassium channels to activate them. Another major focus is the discovery of the molecular mechanisms underlying the beneficial actions of traditional herbal and other botanical medicines. Other interests include discovery of novel ion channel subunits and small molecules to modulate ion channel function, ion channel-transporter interactions, and investigation of ion channel trafficking. Abnormal functioning of ion channels can cause disorders including cardiac arrhythmia, epilepsy, myotonia, ataxia, periodic paralysis, hypothyroidism and cancer. We are employing a multidisciplinary approach aimed at understanding the molecular etiologies of, and ultimately developing therapies for, a wide spectrum of “channelopathies” - human diseases arising from ion channel dysfunction.
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论文共 207 篇作者统计合作学者相似作者
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BRITISH JOURNAL OF PHARMACOLOGYno. 4 (2023): 560-561
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The FASEB Journalno. 9 (2023)
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American journal of physiology. Regulatory, integrative and comparative physiologyno. 6 (2023): R747-R760
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 9 (2023)
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FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 7 (2023)
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Nature chemical biologyno. 11 (2023): 1303-1305
Kiki J Chen,Ryan Yoshimura, Clarissa Adriana Edmundo,Tri Minh Truong,Olivier Civelli,Amal Alachkar,Geoffrey W Abbott
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