Canagliflozin Pretreatment Attenuates Myocardial Dysfunction and Improves Postcardiac Arrest Outcomes After Cardiac Arrest and Cardiopulmonary Resuscitation in Mice.

Feng Ju,Geoffrey W Abbott,Jiaxue Li,Qifeng Wang,Ting Liu,Quanhua Liu,Zhaoyang Hu

Cardiovascular drugs and therapy（2023）

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摘要

Canagliflozin offered a strong cardioprotective effect against cardiac arrest and resuscitation-induced cardiac dysfunction. This canagliflozin-induced cardioprotection is mediated by the STAT-3-dependent cell-survival signaling pathway.

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关键词

Canagliflozin,Cardiac arrest,Cardiopulmonary resuscitation,STAT-3,Sodium-glucose co-transporter 2 (SGLT-2) inhibitors

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