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David Gifford develops new machine learning techniques and algorithms to model the transcriptional regulatory networks that control gene expression programs in living cells.
Our group has a very productive interdisciplinary collaboration with leading biologists that has allowed us to tackle extraordinarily difficult and interesting problems that underlie cellular function and development.
Current work in our laboratory is examining how we can computationally model chromatin modifying complexes that are associated with the genome of living yeast cells. New kinds of mechanistic computational models are necessary to capture how chromatin structure encodes cellular memory, and how the state of this memory is used to control gene expression.
Our group has a very productive interdisciplinary collaboration with leading biologists that has allowed us to tackle extraordinarily difficult and interesting problems that underlie cellular function and development.
Current work in our laboratory is examining how we can computationally model chromatin modifying complexes that are associated with the genome of living yeast cells. New kinds of mechanistic computational models are necessary to capture how chromatin structure encodes cellular memory, and how the state of this memory is used to control gene expression.
研究兴趣
论文共 246 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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arxiv(2023)
Marisa C. Hamilton,James D. Fife,Ersin Akinci,Tian Yu,Benyapa Khowpinitchai,Minsun Cha,Sammy Barkal, Thi Tun Thi,Grace H. T. Yeo, Juan Pablo Ramos Barroso, Matthew Jake Francoeur,Minja Velimirovic,
CELL GENOMICSno. 5 (2023): 100304-100304
Vladimir Abarinov, Joshua A Levine, Angela J Churchill,Bryce Hopwood,Cailin S Deiter,Michelle A Guney,Kristen L Wells, Jessica M Schrunk,Yuchun Guo,Jennifer Hammelman,David K Gifford,Mark A Magnuson,
Genes & developmentno. 11-12 (2023): 490-504
NUCLEIC ACIDS RESEARCHno. 9 (2022): e52-e52
arxiv(2022)
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Tulsi Patel,Jennifer Hammelman, Siaresh Aziz,Sumin Jang,Michael Closser, Theodore L. Michaels,Jacob A. Blum,David K. Gifford,Hynek Wichterle
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