Expert Consensus on the Management of Adverse Events of Lorlatinib in the Treatment of ALK+ Advanced Non-small Cell Lung Cancer
Clinical drug investigation（2024）
Hospital del Mar | La Paz University Hospital | A Coruña University Hospital | Santiago de Compostela University Clinical Hospital | Virgen del Rocío University Hospital | Bellvitge University Hospital | Fundación Jiménez Díaz University Hospital | University Hospital Lozano Blesa | La Fe University and Polytechnic Hospital | Catalan Institute of Oncology | Insular-Maternity and Pediatric University Hospital Complex of Gran Canaria | Pfizer Oncology | Vall d’Hebron University Hospital and Vall d’Hebron Institute of Oncology
Abstract
The use of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs), such as lorlatinib, for the treatment of patients with ALK gene rearrangement (or ALK-positive) non-small cell lung cancer (NSCLC) has been shown to improve the overall survival and quality of life of these patients. However, lorlatinib is not exempt from potential adverse events. Adequate monitoring and management of these adverse events are critical for increasing patient adherence to lorlatinib, thereby maximizing the benefits of treatment and minimizing the risks associated with treatment discontinuation. Considering that the adverse events of lorlatinib can affect different organs and systems, the participation of a multidisciplinary team, including cardiologists, neurologists, internal medicine specialists, and oncology pharmacists, is needed. This article presents specific and pragmatic strategies for identifying and treating the most relevant adverse events associated with lorlatinib in patients with advanced ALK-positive NSCLC based on the clinical experience of a multidisciplinary panel of experts.
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