Supplementary Figures S1-S5 from TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Supplementary figures: Supplementary Figure 1 shows cell viability of human monocyte-derived dendric cells and mouse bone marrow dendritic cells. Supplementary Figure 2 shows mean plasma and tumor concentration-time curves of TAK-676 in BALB/C mice (A20 syngeneic tumors). Supplementary Figure 3 shows percentage body weight change in BALB/C mice (CT26.WT and A20 syngeneic tumors). Supplementary Figure 4 shows percentage body weight change in STING-deficient Goldenticket mice (STING WT and B16F10 syngeneic tumors). Supplementary Figure 5 shows cytokine expression in A20 tumor-bearing mice (plasma and tumor).