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    • Antibiotic Susceptibility of Clinical Burkholderia Pseudomallei Isolates in Northeast Thailand from 2015 to 2018 and the Genomic Characterization of Β -Lactam-resistant Isolates

    Antioxidants（2021）SCI 2区SCI 1区

    Mahidol Univ | Udon Thani Hosp | Mukdahan Hosp | Roi Et Hosp | Surin Hosp | Nakhon Phanom Hosp | Buriram Hosp | Sisaket Hosp | Khon Kaen Hosp | Khon Kaen Univ | Ramathibodi Hosp | Univ Washington

    Cited 10|Views24
    Abstract
    Melioidosis is an often fatal infection in tropical regions caused by an environmental bacterium, Burkholderia pseudomallei . Current recommended melioidosis treatment requires intravenous β-lactam antibiotics such as ceftazidime (CAZ), meropenem (MEM), or amoxicillin-clavulanic acid (AMC) and oral trimethoprim-sulfamethoxazole.
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    Key words
    beta-lactam resistance,penA,melioidosis,genome,Burkholderia pseudomallei,ceftazidime,Thailand
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    【要点】：本研究开发了一种局部化阳离子纳米载体(LION)递送多价自我扩增RNA(repRNA)疫苗，能在小鼠中安全地激发局部免疫反应和特异性适应性免疫应答，同时避免了系统性炎症。
    

    【方法】：采用了局部化阳离子纳米载体(LION)和脂质纳米颗粒(LNPs)两种不同的递送系统来传递多价repRNA。
    

    【实验】：通过LION递送多价repRNA至小鼠肌肉，实现局部高分布和局部免疫反应增强，而LNPs递送则导致repRNA在体内广泛分布，引发系统性炎症和高体重损失，多价配置下无法诱导中和抗体反应。结果显示，LION递送repRNA的安全性和有效性，与LNP递送系统有明显差异。