CSF1R Inhibition Promotes Neuroinflammation and Behavioural Deficits During Graft-Versus-host Disease in Mice.

Rachael C. Adams,Dylan Carter-Cusack,Genesis T. Llanes,Christopher R. Hunter,Janaki Manoja Vinnakota,Marc Ruitenberg,Jana Vukovic,Patrick Bertolino,Kirat K. Chand,Julie A. Wixey, Samuel P. Nayler,Geoffrey R. Hill,Scott N. Furlan,Robert Zeiser,Kelli P. A. MacDonald

BLOOD（2023）

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摘要

•Antibody-mediated CSF1R inhibition is associated with neurological toxicity during acute and chronic CNS GVHD.•Targeting donor IFNGR signalling is a promising therapeutic strategy for ameliorating chronic GVHD of the CNS.

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关键词

Graft-versus-Host Disease

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